title: Prospects for the treatment of patients with chronic viral hepatitis with cirrhosis
metadata.name: dc.contributor.author
metadata.value: Volkov, Eduard V.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Sokolova, Ol’ga I.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Komarova, Aleksandra Ya.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Karavaeva, Aleksandra A.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Yakovlev, Aleksei A.
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2018-04-25T09:58:38Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2018-04-25T09:58:38Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2018-03
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Volkov E. V., Sokolova O. I., Komarova A. Ya., Karavaeva A. A., Yakovlev A. A. Prospects for the treatment of patients with chronic viral hepatitis with cirrhosis. Vestnik of Saint Petersburg University. Medicine, 2018, vol. 13, issue 1, pp. 16–23.
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: 10.21638/11701/spbu11.2018.102
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/9447
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: We performed a retrospective cohort study at S. P. Botkin Clinical Infectious Diseases Hospital, St. Petersburg, Russia from January to December 2014. The purpose of this study was to evaluate indications and contraindications for liver transplant in cirrhotic patients with chronic hepatitis. We analyzed 310 medical record of patients with established diagnosis “Chronic viral hepatitis, cirrhosis”. According to the EASL 2015, 59.4 % (184) of patients with liver cirrhosis had one or multiple indications for liver transplantation. 64.1 % (118) patients were of working age. Chronic hepatitis C virus infection was detected in 56.3 % (71). The most significant contraindication was active alcohol or drug addiction: 76 % (44). Extrahepatic malignant neoplasms detected in 19 % (11) and active extrahepatic infection in 5 % (3). Risk factors of mortality during the current hospitalization were significantly associated with the MELD score, the presence of hepatocellular carcinoma, active alcoholism, active extrahepatic infection and extrahepatic malignant neoplasms. Among patients hospitalized with the diagnosis “Chronic viral hepatitis, cirrhosis”, 40 % (126) had indications and had no contraindications for liver transplantation. Under the conditions of an insufficient number of liver transplantations, high mortality, especially in working-age patients with no contraindications for this operation, it is necessary to find early treatment with effective influence on the pathological mechanisms to prevent the need for liver transplantation.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: ru
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Vestnik of St Petersburg University. Medicine;Volume 13; Issue 1
metadata.lang: -
metadata.name: dc.subject
metadata.value: liver cirrhosis
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: decompensated cirrhosis
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: liver transplantation
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: chronic hepatitis C virus infection
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: MELD score
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Prospects for the treatment of patients with chronic viral hepatitis with cirrhosis
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 02-Volkov.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/9447/1/02-Volkov.pdf
resources.format: Adobe PDF
resources.size: 621,92 kB