title: The issue of nosocomial infection caused by Klebsiella pneumoniae blaNDM-type
metadata.name: dc.contributor.author
metadata.value: Mironenko, Olga V.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Selnitseva, Victoria V.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Soprun, Lidia A.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Shmushkevich, Elena N.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Alekseev, Andrey A.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Ivanov, Aial S.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Тоvanova, Anna A.
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2021-02-04T11:08:52Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2021-02-04T11:08:52Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2020-06
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Mironenko O. V., Selnitseva V. V., Soprun L. A., Shmushkevich E. N., Alekseev A. A., Ivanov A. S., Тоvanova A. A. The issue of nosocomial infection caused by Klebsiella pneumoniae blaNDM-type. Vestnik of Saint Petersburg University. Medicine, 2020, vol. 15, issue 2, pp. 124–133.
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/spbu11.2020.204
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/23407
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: The article presents information about circulating isolates Klebsiella pneumoniae in a hospital
  megapolis with properties of hypervirulence and simultaneous multiresistance. The resulting
  K. pneumonia isolates are of particular importance due to the emergence of resistance to almost
  all β-lactams due to the presence of carbapenemase metal-β-lactamase. Furthermore, the isolated
  strains producing carbapenemases possess mechanisms of resistance to a wide range of antimicrobial
  preparations, and the types of infectious process caused by carbapenemazo-producing
  enterobacteries are characterized by a high lethality level. Microbiological, biochemical, biophysical,
  molecular-genetic, biological, bioinformational and statistical methods of research were
  used in the work. A prospective method was used to identify the source of the infections. In the
  first stage, a microbiological study was carried out on biomaterials obtained from patients treated
  in a hospital in Saint Petersburg. After a microbiological study, 52 isolates of K. pneumoniae
  were obtained, 53.8 % of isolates had a hypermucoid phenotype and 98 % had carbapenemases:
  blaNDM type — 49 (92 %), blaNDM+OXA-48-like — 3 (8 %). Isolates with two new phenotypes
  have been isolated (no. 2511 and no. 2512). Isolates of no. 2512 LD50 had 10*2 BAC/ml, and
  plasmids such as Incfib(Mar), Inchi1b, and Incr were also found, with Incr-A plasmid emitted
  encoding resistance to fluoroquinolone: aac(6’)-Ib-cr and to β-lactam antibiotics: blaTEM-1B.
  The described data confirm the opinions of the researchers about the possible formation of a new
  “super pathogen” — instantaneously hypervirulent and plural resistant strain of K. pneumoniae.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Vestnik of St Petersburg University. Medicine;Volume 15; Issue 2
metadata.lang: -
metadata.name: dc.subject
metadata.value: K. pneumonia blaNDM
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: nosocomial infection
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: epidemiological process
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: carbapenemaza
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: hypervirulence
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: The issue of nosocomial infection caused by Klebsiella pneumoniae blaNDM-type
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 124-133.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/23407/1/124-133.pdf
resources.format: Adobe PDF
resources.size: 1,23 MB