title: Method of closing the residual cavity with composite material “LitAr” in combination with an antibiotic for chronic pleural empyema and features of reparative histogenesis
metadata.name: dc.contributor.author
metadata.value: Mukhammedov, Khan Bogdat M.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Shevlyuk, Nikolai N.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Tretyakov, Anatoly A.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Stadnikov, Alexander A.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Fadeev, Sergey B.
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2017-08-20T14:18:14Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2017-08-20T14:18:14Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2017-06
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Mukhammedov Kh. B. M., Shevlyuk N. N., Tretyakov A. A., Stadnikov A. A., Fadeev S. B. Method of closing the residual cavity with composite material “LitAr” in combination with an antibiotic for chronic pleural empyema and features of reparative histogenesis. Vestnik SPbSU. Medicine, 2017, vol. 12, issue 2, pp. 154–160.
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: 10.21638/11701/spbu11.2017.204
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/7035
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: Our research examines the features of reparative histogenesis in liquidation of rigid residual cavity
  in chronic pleural empyema by means of a composite material. An experiment was conducted using
  30 laboratory rats to model limited chronic pleural empyema (formed by implantation in the right
  half of the chest cavity a silicone bead with a 9mm diameter) and determine the use of the composite
  material “LitAr” in combination with an antibiotic to eliminate a rigid residual cavity in chronic pleural
  empyema. The cavity over the course of 20 days observation was infected with the introduction of
  0.5 ml of overnight culture suspension of 105 CFU of Klebsiella pneumonia (strain GISCO № 278).
  To create a model of limited chronic empyema it took 38 days. Then the infected cavity was filled
  with composite material and the antibiotic cefazolin was administered intramuscularly in the dose of
  20 mg/kg two times per day for 10 days. The area subjected to sealing composite material was then excised
  for subsequent morphological study. The data showed that the combination of composite “LitAr”
  antibiotic accelerated vasculogenesis, optimized cell proliferation and fibroblast cytodifferentiation
  differon. This resulted in the migration of a large number of differentiated fibroblasts to the composite
  material. These formed on the site of the liquidated cavity as loose irregular connective tissue. Refs 12.
  Figs 4.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: ru
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Vestnik of St Petersburg University. Medicine;Volume 12; Issue 2
metadata.lang: -
metadata.name: dc.subject
metadata.value: residual pleural cavity
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: empyema
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: regeneration
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: connective tissue
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: composite material
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Method of closing the residual cavity with composite material “LitAr” in combination with an antibiotic for chronic pleural empyema and features of reparative histogenesis
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 04-Mukhammedov.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/7035/1/04-Mukhammedov.pdf
resources.format: Adobe PDF
resources.size: 1,59 MB