title: Mucosal vaccine based on attenuated influenza virus and the group B Streptococcus recombinant peptides protected mice from influenza and S. pneumoniae infections
metadata.name: dc.contributor.author
metadata.value: Desheva, Yulia
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2019-06-26T15:36:01Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2019-06-26T15:36:01Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2019-06-26
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/15769
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: Although many influenza-related deaths are attributable to secondary bacterial infection
  with S. pneumoniae, vaccines that simultaneously protect against influenza and pneumococcal infection are currently not developed. The aim of our study was to evaluate the possibility to prevent post-influenza pneumococcal infection using an associated vaccine based
  on live influenza vaccine (LAIV) combined with recombinant polypeptides derived from
  superficial factors of Group B streptococcus (GBS) determining pathogenicity. We demonstrated in a model of post-influenza pneumococcal pneumonia that intranasal pneumococcal super-infection seriously complicated the course of A/Shanghai/2/2013(H7N9) CDC-RG
  virus infection in mice. Associated immunization using LAIV and GBS vaccine (GBSV) prevented post-influenza pneumococcal pneumonia better than mono-LAIV or GBSV immunization. At the same time, parenteral pneumococcal post-influenza infection of immune mice
  was more severe in the groups immunized using recombinant GBS peptides which can be
  explained by antibody-dependent enhancement of infection. In this case, the introduction of
  blockers of histamine receptors type 1 and 2 reduced the burden of secondary pneumococcal infection
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: Plos One
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Mucosal vaccine based on attenuated influenza virus and the group B Streptococcus recombinant peptides protected mice from influenza and S. pneumoniae infections
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: journal.pone.0218544.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/15769/1/journal.pone.0218544.pdf
resources.format: Adobe PDF
resources.size: 1,93 MB