title: Evaluation of the cytokine profile and vascular elasticity in middle-aged men with essential hypertension and combined pathology
metadata.name: dc.contributor.author
metadata.value: Lebedeva, Irina A.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Kryukov, Evgeny V.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Tsygan, Vasily N.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Partsernyak, Alexander S.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Magradze, Guram N.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Ustyuzhaninov, Vitaly S.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Ayvazyan, Bella G.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Partsernyak, Sergey A.
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2022-08-12T14:00:30Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2022-08-12T14:00:30Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2022-03
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Lebedeva I. A., Kryukov E. V., Tsygan V. N., Partsernyak A. S., Magradze G. N., Ustyuzhanin V. S., Ayvazyan B. G., Partsernyak S. A. Evaluation of the cytokine profile and vascular elasticity in middle-aged men with essential hypertension and combined pathology. Vestnik of Saint Petersburg University. Medicine, 2021, vol. 16, issue 4, pp. 234–245.
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/spbu11.2021.402
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/37355
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: The diagnosis and management of patients with polymorbid cardiovascular pathology is a
  significant challenge. The pathogenesis of many cardiovascular diseases, such as arterial hypertension,
  coronary heart disease, angina pectoris, as well as diabetes mellitus, obesity and
  dyslipidemia are associated with systemic inflammation. The inflammatory process, both at
  the systemic and local levels, can make a significant contribution to the progression of atherosclerosis
  and endothelial dysfunction, and provoke the destabilization of blood pressure.
  Therefore, it is important to develop new approaches to the identification of patients with
  polymorbid pathology and chronic inflammatory processes in the body. It is known that the
  presence of the oral cavity inflammation increases the risk of cardiovascular disease. Periodontal
  pathology, leading to an increased expression of pro-inflammatory cytokines, affects
  the initiation of atherosclerosis, endothelial dysfunction, vasospasm, and blood pressure dysregulation.
  It can be assumed that the oral cavity inflammatory processes against the arterial
  hypertension increase the probability of early vascular aging, the overall cardiovascular risk,
  and also increase the chance of other diseases of the cardiological profile The research subject
  was to determine the vascular elasticity parameters and the dynamics of blood pressure daily
  profile, as well as the level of pro-inflammatory and anti-inflammatory cytokines in persons
  with arterial hypertension, considering the presence of inflammatory processes in the oral
  cavity. The structure of comorbidity and a number of laboratory and instrumental data of
  middle-aged men with arterial hypertension in combination with periodontitis were analyzed
  in comparison with patients with arterial hypertension without periodontitis and healthy volunteers
  of the same age. A correlation was shown between the periodontal inflammation level
  in men with arterial hypertension and the polymorbid cardiovascular pathology presence (diabetes
  mellitus, dyslipidemia, anxiety and depressive disorders, coronary heart disease, signs
  of left ventricular hypertrophy by ECG, high ankle-brachial index as a marker of peripheral
  atherosclerosis), significant variability in blood pressure, an altered cytokine profile with a predominance of pro-inflammatory cytokines, an increase in “vascular age” on the ASCORE
  scale, and increased vascular stiffness, assessed by 24-hour blood pressure monitoring using
  the “VasotensOffice” program.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Vestnik of St Petersburg University. Medicine;Volume 16; Issue 4
metadata.lang: -
metadata.name: dc.subject
metadata.value: blood vessels elasticity
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: blood pressure variability
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: arterial hypertension
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: cytokines
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: periodontitis
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: polymorbidity
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Evaluation of the cytokine profile and vascular elasticity in middle-aged men with essential hypertension and combined pathology
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 02.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/37355/1/02.pdf
resources.format: Adobe PDF
resources.size: 656,75 kB