title: Allogeneic bone marrow mesenchymal stem cells in the epineurium and perineurium of the recipient rat
metadata.name: dc.contributor.author
metadata.value: Petrova, Elena
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Isaeva, Elena
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Kolos, Elena
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Korzhevskii, Dmitrii
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2018-09-03T13:03:31Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2018-09-03T13:03:31Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2018-06
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Petrova, E., Isaeva, E., Kolos, E., and Korzhevskii, D. 2018. Allogeneic bone marrow mesenchymal stem cells in the epineurium and perineurium of the recipient rat. Bio. Comm. 63(2): 123–132.
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: 10.21638/spbu03.2018.205
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/14760
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: Achievements in regenerative medicine have demonstrated that using different
  kinds of stem cells can have some stimulating effect on the reparative regeneration
  processes of the nervous system. To stimulate nerve regeneration,
  the experimental elaboration of mesenchymal stem cell (MSC) transplantation
  is carried out actively. There is evidence that MSCs promote growth of the recipient
  regenerating axons after transplantation into the damaged nerve or the
  conduit. However, processes that happen in transplanted cells and these cells’
  differentiation are poorly studied. The aim of the present study is to describe
  the localization and morphologically peculiar properties of bone marrow-derived
  mesenchymal stem cells after their allotransplantation into the injured
  nerve of a rat. MSCs from Wistar—Kyoto rats were cultivated for seven days
  and labeled with BrdU three days before using. The sciatic nerves of adult Wistar—
  Kyoto rats were damaged, and suspensions of BrdU-labeled cultured
  MSCs were immediately transplanted into the damaged sciatic nerves. Five to
  seven days after transplantation, the surviving MSCs were found. Using fluorescent
  microscopy, we found that some of the transplanted cells were localized
  in the epineurium and in the perineurium. Some of the transplanted MSCs differentiated
  into adipocytes and cells of the perineurium.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Biological Communications;Volume 63; Issue 2
metadata.lang: -
metadata.name: dc.subject
metadata.value: MSCs
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: differentiating
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: nerve
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: epineurium
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: perineurium
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: adipocytes
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: immunohistochemistry
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: fluorescence microscopy
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Allogeneic bone marrow mesenchymal stem cells in the epineurium and perineurium of the recipient rat
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 05-Petrova.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/14760/1/05-Petrova.pdf
resources.format: Adobe PDF
resources.size: 1,23 MB