title: Modern aspects of pathogenesis of calcification of the aortic valve
metadata.name: dc.contributor.author
metadata.value: Gulyaev, Nikolay I.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Varavin, Nikita A.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Korovin, Alexander E.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Kuznetsov, Valery V.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Yakovlev, Vladimir V.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Gordienko, Alexandr V.
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2017-01-27T13:52:51Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2017-01-27T13:52:51Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2016-09
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Gulyaev N. I., Varavin N. A., Korovin A. E., Kuznetsov V. V., Yakovlev V. V., Gordienko A. V. Modern aspects of pathogenesis of calcification of the aortic valve. Vestnik of Saint Petersburg University. Series 11. Medicine, 2016, issue 3, pp. 20–34.
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: 10.21638/11701/spbu11.2016.302
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/5957
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: Aortic valve calcification with accompanying stenosis is the predominant reason for cardiac valve replacement.
  Lack of medical treatments, together with a high frequency of occurrence of calcific aortic
  stenosis represent one of the main problems in cardiological practice. New observations in human
  aortic valves support the hypothesis that calcific valvular aortic stenosis is the result of active bone
  formation in the aortic valve, which may be mediated through a process of osteoblast-like differentiation
  in these tissues. Although there are similarities with the risk factor as well as with the process of
  atherogenesis, not all the patients with coronary artery disease or pathogenesis exhibit aortic valve stenosis.
  Modern pathogenesis of the calcific aortic stenosis is presented in the article which also provides
  its comparative characteristics with atherosclerosis. Refs 51. Figs 3. Table 1.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: ru
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Vestnik of St Petersburg University. Series 11. Medicine;Issue 3
metadata.lang: -
metadata.name: dc.subject
metadata.value: aortic valve
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: aortic stenosis
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: сalcification
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: osteoprotegerin
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: RANKL
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: RANK
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: atherosclerosis
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: endothelial dysfunction
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: matrix metalloproteinases
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: Wnt signaling
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Modern aspects of pathogenesis of calcification of the aortic valve
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 02-Gulyaev.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/5957/1/02-Gulyaev.pdf
resources.format: Adobe PDF
resources.size: 1,19 MB