title: Factor analysis of leptin, adiponectin effect and resistin during bronchial asthma
metadata.name: dc.contributor.author
metadata.value: Lalaeva, Тatiana M.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Mineev, Valery N.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Тrofimov, Vasily I.
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2021-03-12T14:07:59Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2021-03-12T14:07:59Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2020-09
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Lalaeva T. M., Mineev V. N., Trofimov V. I. Factor analysis of leptin, adiponectin effect and resistin during bronchial asthma. Vestnik of Saint Petersburg University. Medicine, 2020, vol. 15, issue 3, pp. 173–176.
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/spbu11.2020.301
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/25422
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: To date, the participation of particular adipokines (leptin, adiponectin, resistin) in the pathogenesis
  of bronchial asthma has been well studied, however, their interaction, in particular
  their cooperative effect on the course of the disease, has not been practically studied. The
  aim of the study is to identify the effect of the cooperative interaction of key adipokines on
  the course of bronchial asthma, depending on the pathogenetic variant of the disease. Factor
  analysis was used to analyze the data from the study of the levels of leptin, adiponectin, resistin
  in 56 patients with bronchial asthma. Factor analysis made it possible to identify 3 factors.
  Factor 1 reflects the direct effect of leptin signaling on the severity of bronchial asthma, to
  a lesser extent on the exacerbation of the disease. In this case, the adiponectin component,
  with a high negative factor load, is associated with the severity of the course and the phase of
  bronchial asthma. Factor 2 reflects the direct effect of another adipokine resistin on the severity
  of bronchial asthma, but we draw attention to the fact that the resistin component with a
  large positive factor loading is associated with a non-allergic variant of bronchial asthma and
  exacerbation of the disease. Factor analysis revealed a fundamentally different pathogenetic
  role in relation to the severity of bronchial asthma of such adipokines as leptin and resistin in
  different variants of the disease.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Vestnik of St Petersburg University. Medicine;Volume 15; Issue 3
metadata.lang: -
metadata.name: dc.subject
metadata.value: leptin
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: adiponectin
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: resistin
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: bronchial asthma
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: severity of the course
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: factor analysis
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Factor analysis of leptin, adiponectin effect and resistin during bronchial asthma
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 9846-Article Text-30716-1-10-20210222.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/25422/1/9846-Article%20Text-30716-1-10-20210222.pdf
resources.format: Adobe PDF
resources.size: 600,79 kB