title: Circulating biomarker profile changes in obese patients undergoing bariatric surgery
metadata.name: dc.contributor.author
metadata.value: Sushentseva, Natalya
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Apalko, Svetlana
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Popov, Oleg
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Polkovnikova, Irina
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Vasiliev, Evgeny
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Gladyshev, Dmitriy
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Salukhov, Vladimir
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Scherbak, Sergey
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2024-06-07T12:05:36Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2024-06-07T12:05:36Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2024-03
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Sushentseva, N., Apalko, S., Popov, O., Polkovnikova, I., Vasiliev, E., Gladyshev, D., Salukhov, V., and Scherbak, S. 2024. Circulating biomarker profile changes in obese patients undergoing bariatric surgery. Bio. Comm. 69(1): 26–36. https://doi.org/10.21638/spbu03.2024.103
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/spbu03.2024.103
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/45569
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: Bariatric surgery (BS) remains the most effective treatment for morbid obesity
  (MO). It’s relevant to identify biomarkers for predicting the outcome of BS in
  patients with MO. The aim of the study was to determine the dynamical change
  in the biomarker levels in patients undergoing BS and apparently healthy donors.
  Serum and plasma samples were obtained from 66 patients, of which
  26 patients with MO (aged 26–72 years) underwent BS, and 40 healthy donors,
  at the age of 56 ± 10.3 years. Patient samples were obtained the day before
  BS (first group), 3–7 months after BS (second group), and 7 or more months
  after BS (third group). Analyte concentrations were determined by multiplex
  immunoassay on the xMAP platform (Luminex). Spearman’s rank correlation
  was used. The nature of analyte variability was described by building multiple
  regression models. In the patients compared with healthy controls, differences
  in the levels of resistin, PAI1, MCP1, GLP1, leptin, FGF23, adiponectin, adipsin
  were observed. In patients after BS, the levels of resistin, ANGPTL6, FGF21, and
  leptin changed. In patients over 55 years old compared with younger patients,
  differences for total ANGPTL4, amylin, and pancreatic polypeptide were observed.
  Differences in levels of glucagon, resistin, GLP1 and leptin were noted
  between men and women. The dynamics of the levels of adipokines and incretins
  indicates biochemical changes in patients after BS compared with healthy
  persons.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Biological Сommunications;Volume 69; Issue 1
metadata.lang: -
metadata.name: dc.subject
metadata.value: obesity
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: biomarkers
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: bariatric surgery
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: weight loss
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: body weight
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Circulating biomarker profile changes in obese patients undergoing bariatric surgery
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: BioComm_69_1_26-36.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/45569/1/BioComm_69_1_26-36.pdf
resources.format: Adobe PDF
resources.size: 713,66 kB