title: The human placenta and aneuploidy — trisomies 21, 18, 13
metadata.name: dc.contributor.author
metadata.value: Kolobov, Andrey V.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Lychyova, Anna Z.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Karev, Vadim E.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Kolobova, Oksana L.
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2020-11-20T17:03:08Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2020-11-20T17:03:08Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2020-03
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Kolobov A.V., Lychyova A.Z., Karev V.Е., Kolobova O.L. The human placenta and aneuploidy — trisomies 21, 18, 13. Vestnik of Saint Petersburg University. Medicine, 2020, vol. 15, issue 1, pp. 24–31.
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/spbu11.2020.103
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/20800
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: The purpose of this research was to investigation the morphological features of human placenta
  with karyotyped trisomy 21, 18 and 13 chromosomes. The study included 50 placenta of fetuses
  in miscarriages pregnancy at 19–20 weeks, among them 10 placentas obtained as a result of
  induced abortions due to karyotyped trisomy 21 of the fetuses; 10 placentas obtained as a result
  of induced abortions due to karyotyped trisomy 18 of the fetuses; 10 placentas obtained as a
  result of induced abortions due to karyotyped trisomy 13 in the fetuses; 20 placentas obtained as
  a result of spontaneous miscarriages without any congenital defects and abnormal karyotype of
  the fetuses. As a result of the investigation, in placentas with karyotyped trisomies, a violation of
  villi branching was noted. With karyotyped trisomy 21, inhibition of angiogenesis and sclerosis
  of villi with proliferation of fibroblasts were revealed. In cells of chorionic villi with karyotyped
  trisomy 18, increased apoptosis was noted. In placentas with karyotyped trisomy 13 hydropic
  changes in villus stroma and inhibition of angiogenesis were noted.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Vestnik of St Petersburg University. Medicine;Volume 15; Issue 1
metadata.lang: -
metadata.name: dc.subject
metadata.value: trisomy
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: placenta
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: immunohistochemical analysis
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: angiogenesis
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: apoptosis
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: The human placenta and aneuploidy — trisomies 21, 18, 13
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 24-31.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/20800/1/24-31.pdf
resources.format: Adobe PDF
resources.size: 4,39 MB