title: From past to future: suppressor mutations in yeast genes encoding translation termination factors
metadata.name: dc.contributor.author
metadata.value: Trubitsina, Nina
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Zemlyanko, Olga
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Moskalenko, Svetlana
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Zhouravleva, Galina
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2019-08-28T20:53:20Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2019-08-28T20:53:20Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2019-06
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Trubitsina, N., Zemlyanko, J., Moskalenko, S., and Zhouravleva, G. 2019. From past to future: suppressor mutations in yeast genes encoding translation termination factors. Bio. Comm. 64(2): 89–109.
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/spbu03.2019.202
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/16206
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: The study of the SUP45 and SUP35 genes of yeast Saccharomyces cerevisiae in the laboratory of Physiological Genetics of St. Petersburg State University began in 1964 when the first omnipotent nonsense suppressor mutations were obtained. During the following 55 years, a lot of information about these genes has been gained through the research efforts of various laboratories. Now we know that SUP45 and SUP35 encode translation termination factors eRF1 and eRF3, respectively. Both genes are essential, and sup45 and sup35 mutations lead not only to impaired translation but also to multiple pleiotropic effects. The aim of this review is to summarize known data about suppressor mutations in SUP45 or SUP35 genes.
metadata.lang: en_GB
metadata.name: dc.description.sponsorship
metadata.value: This work was supported by grants from the Russian Science Foundation (Grant 18-14-00050) (parts 1-5) and the Russian Foundation for Basic Research (Grant 19-04-00173) (part 6: “Suppression due to prion [PSI+]”); modelling of the 3D structure of eRF1-eRF3C-GDPNP protein complex with suppressor missense mutations was done in the frame of the State Research Program (0112-2016-0015).
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Biological Communications;Volume 64; Issue 2
metadata.lang: -
metadata.name: dc.subject
metadata.value: translation termination
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: suppression
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: SUP45
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: SUP35
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: eRF1
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: eRF3
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: nonsense mutations
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: missense mutations
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: [PSI+] prion
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: S. cerevisiae
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: From past to future: suppressor mutations in yeast genes encoding translation termination factors
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 89-109.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/16206/1/89-109.pdf
resources.format: Adobe PDF
resources.size: 1,23 MB