title: Single-nucleotide Polymorphisms of AGT, SOD2, CAT in Risk Estimates for Arterial Hypertension among Young People
metadata.name: dc.contributor.author
metadata.value: Kovaleva, Alexandra V.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Astratenkova, Irina V.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Golovanova, Natalya E.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Orlova, Olga G.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Rybalchenko, Oksana V.
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2019-11-26T13:24:08Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2019-11-26T13:24:08Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2019-06
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Kovaleva A. V., Astratenkova I. V., Golovanova N. E., Orlova O. G., Rybalchenko O. V. Single-nucleotide Polymorphisms of AGT, SOD2, CAT in Risk Estimates for Arterial Hypertension among Young People. Vestnik of Saint Petersburg University. Medicine, 2019, vol. 14, issue 2, pp. 141– 146.
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/spbu11.2019.206
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/16652
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: Arterial hypertension is one of the most common cardiovascular diseases and one of the main
  causes of mortality and disability of population. Opportunity to predict emergence of arterial
  hypertension and to take preventive measures in pre-nosological diagnostics of disease arouse
  research interest in this issue. Possibility to predict progression of arterial hypertension based on
  polymorphic variants of AGT gene (C521T, rs4762) identification, which encodes angiotensinogen
  protein in combination with polymorphic variants of CAT (–262C/T, rs1001179), encoding
  catalase, and polymorphic variants of SOD2 (C47T, rs4880), encoding mitochondrial superoxide
  dismutase, are discussed in this article. Decrease of antioxidant enzymes (catalase and superoxide
  dismutase) activity leads to accumulation of reactive oxygen species in cells. They may
  activate NF-kB transcription factor, which increases expression of individual genes involved in
  sodium homeostasis and in blood pressure control, including angiotensinogen. Increased angiotensinogen
  concentration in blood constitutes a risk factor in arterial hypertension development.
  In our opinion, combination of polymorphic variants of AGT, CAT and SOD genes
  expands the possibilities of personalized medicine.Performed investigation involved 65 medical
  students of St Petersburg State University. DNA was extracted from epithelial cells of the
  oral cavity. Genotyping of DNA samples was determined by real-time PCR. Obtained results of
  our investigation enabled to reveal AGT genotypes associated with hypertension in 12 students.
  The article discusses combinations of TT and CT genotypes of AGT with unfavorable alleles of
  antioxidant enzymes.Carriers of heterozygous SOD2 genotype and homozygous CC genotype
  CAT are in more unfavorable conditions compared to carriers of the CC genotype SOD2 and СТ
  genotype CAT, as SOD2 is a key antioxidant enzyme protecting from ROS.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Vestnik of St Petersburg University. Medicine;Volume 14; Issue 2
metadata.lang: -
metadata.name: dc.subject
metadata.value: arterial hypertension
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: genetic polymorphism
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: angiotensinogen
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: superoxide dismutase
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: catalase
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Single-nucleotide Polymorphisms of AGT, SOD2, CAT in Risk Estimates for Arterial Hypertension among Young People
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 141-146.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/16652/1/141-146.pdf
resources.format: Adobe PDF
resources.size: 1,03 MB