title: Old wine in new wineskins. Hamman-rich syndrome has much in common with severe COVID-19: Do they share any link of pathogenesis or depend on the similar aetiological factor(s)?
metadata.name: dc.contributor.author
metadata.value: Ivashkevich, Yana V.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Korovin, Alexander E.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Petyaeva, Alina V.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Churilov, Leonid P.
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2021-02-04T10:25:05Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2021-02-04T10:25:05Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2020-06
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Ivashkevich Ya. V., Korovin A. E., Petyaeva A. V., Churilov L. P. Old wine in new wineskins. Hamman-rich syndrome has much in common with severe COVID-19: Do they share any link of pathogenesis or depend on the similar aetiological factor(s)? Vestnik of Saint Petersburg University. Medicine, 2020, vol. 15, issue 2, pp. 93–106.
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/spbu11.2020.201
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/23396
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: For the first time the acute interstitial pneumonitis as a main cause of adult idiopathic respiratory
  distress syndrome was described in 1933–35 by the American medical scholars Louis Virgil
  Hamman and Arnold Rice Rich as “acute fibrosing alveolitis” later given the eponymous name
  Hamman-Rich syndrome. This disease targets the interstitium of the lungs and characterized by
  fulminant onset, acute respiratory disorder with possibility of respiratory failure, being clinically
  similar to respiratory distress syndrome with the pathomorphologically revealed diffuse alveolar
  damage. Hamman-Rich syndrome is characterized by rapid progression from symptoms of
  common cold such as cough, fever, chills and dyspnea to severe respiratory failure. The syndrome
  affects apparently healthy individuals and is not associated with any anamnestic chronic
  lung diseases, smoking habits, neither with patients’ age or sex. The aetiology and pathogenesis
  of the Hamman-Rich syndrome are not clear yet. The familiar genetic predisposition is of definite
  meaning, especially related to mutations of surfactant proteins and their metabolism. The
  possible mechanistic links of this fulminant lung disease involve: NK-cells, auto-aggressive immune
  activation and certain types of cytokines during their excessive systemic action, so-called
  cytokine storm (e.g. interleukin-18 and interleukin-2), which play the leading part in the pathogenesis of acute lung cell injury resulting in diffuse non-remitting pneumofibrosis. But all these
  clinical and pathogenetic features are also common for severe COVID-19. Computed tomography
  is used for instrumental diagnosis of Hamman-Rich syndrome and also gives the lung images
  quite similar to that of COVID-19, including ground glass opacity symptoms. The authors
  hypothesize that the same link(s) of pathogenesis underlie the severe course of COVID-19 and
  Hamman-Rich syndrome. It is possible that cases of Hamman-Rich syndrome were due to the
  circulation in populations of a less virulent, unrecognized coronavirus, which interacts with the
  immune system of genetically susceptible individuals in a way similar to SARS-CoV2. For sure,
  the identification of the characteristics of the genome of patients with Hamman-Rich syndrome
  will shed light on the genetic mechanisms that predispose to the severe course of COVID-19
  and vice versa — the experience of severe COVID-19 treatment can be applied to the therapy of
  Hamman-Rich syndrome as well.
metadata.lang: en_GB
metadata.name: dc.description.sponsorship
metadata.value: The work is supported by a grant from the Government of the Russian Federation (contract
  14.W03.31.0009 of 13.02.2017) for state support of scientific research conducted under the supervision of
  leading scientists.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Vestnik of St Petersburg University. Medicine;Volume 15; Issue 2
metadata.lang: -
metadata.name: dc.subject
metadata.value: autoimmunity
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: acute fibrosing alveolitis
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: acute interstitial pneumonia
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: COVID-19
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: Hamman-Rich syndrome
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: acute respiratory distress syndrome
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: cytokine storm
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: complement C3
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: interleukin-18
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: macrophages
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: natural killers
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: surfactant proteins
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Old wine in new wineskins. Hamman-rich syndrome has much in common with severe COVID-19: Do they share any link of pathogenesis or depend on the similar aetiological factor(s)?
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 93-106.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/23396/1/93-106.pdf
resources.format: Adobe PDF
resources.size: 627,01 kB