title: Changes in the gut bacteria composition associated with metabolic syndrome
metadata.name: dc.contributor.author
metadata.value: Kotrova, Anna D.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Shishkin, Alexandr N.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Pchelin, Ivan Yu.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Hudiakova, Natalia V.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Gladyshev, Nikita S.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Ermolenko, Elena I.
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2022-09-20T17:26:21Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2022-09-20T17:26:21Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2022-03
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Kotrova A. D., Shishkin A. N., Pchelin I. Yu., Hudiakova N. V., Gladyshev N. S., Ermolenko E. I. Changes in the gut bacteria composition associated with metabolic syndrome. Vestnik of Saint Petersburg University. Medicine, 2022, vol. 17, issue 1, pp. 14–26.
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/spbu11.2022.102
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/37835
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: Obesity, arterial hypertension, disorders of carbohydrate and lipid metabolism, which form the
  metabolic syndrome, remain the leading risk factors for the development of cardiovascular complications
  and oncological diseases. Overnutrition and a sedentary lifestyle leading to the metabolic
  syndrome formation are also interconnected with another potential pathogenetic factor of
  obesity, the gut microbiota. The study of its composition, as well as its metabolites, can serve as
  a basis for predicting metabolic disorders and for the development of an integrated approach to
  the metabolic syndrome treatment using probiotic therapy. The clinical assessment of the gut
  microbiota composition in patients with MS was carried out to identify bacterial taxa potentially
  associated with the development of MS. Materials (feces) were collected from 113 patients: the
  first group (n = 59) consisted of overweight patients (body mass index > 25.0) with metabolic disorders
  in the form of lipid and/or carbohydrate disorders (the average age 44 years). The control
  group (n = 54) consisted of patients with normal body weight (18.5 < body mass index < 25.0),
  without metabolic disorders, without arterial hypertension (the average age — 38 years). Fecal
  samples from patients were studied using 16S rRNA gene sequencing on the Illumina platform
  (MiSeq sequencer). The CDHIT-OTU-Miseq program was used to search for taxonomic units.
  Deoxyribonucleic acid libraries were prepared using the Illumina Nextera sample preparation
  kit with deoxyribonucleic acid primers corresponding to the V3–V4 regions of the 16S rRNA
  gene. In the gut microbiota composition of patients with metabolic syndrome we can highlight
  the phylum Actinobacteria, its 2 genera Actynomyces spp. and Bifidobacterium spp., as well as
  the genus Prevotella spp. and the class Gammaproteobacteria. It is assumed that bacterial species
  belonging to these type, class, and genera can be considered as potential marker bacteria of the
  metabolic syndrome.
metadata.lang: en_GB
metadata.name: dc.description.sponsorship
metadata.value: The study was financially supported by the Russian Foundation for Basic Research under research
  project no. 20-315-90106.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Vestnik of St Petersburg University. Medicine;Volume 17; Issue 1
metadata.lang: -
metadata.name: dc.subject
metadata.value: gut microbiota
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: metabolic syndrome
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: obesity
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: 16s rRNA
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: Actinobacteria
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: Bifidobacterium
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Changes in the gut bacteria composition associated with metabolic syndrome
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 12950-Текст статьи-46466-1-10-20220804.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/37835/1/12950-%d0%a2%d0%b5%d0%ba%d1%81%d1%82%20%d1%81%d1%82%d0%b0%d1%82%d1%8c%d0%b8-46466-1-10-20220804.pdf
resources.format: Adobe PDF
resources.size: 1,99 MB