title: Influence of subchronic exposure to manganese carried by female rats during pregnancy on the behavioral and cognitive abilities of their offspring at later stages of postnatal development
metadata.name: dc.contributor.author
metadata.value: Kazakova, Tatiana
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Marshinskaya, Olga
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Notova, Svetlana
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2024-06-07T12:00:36Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2024-06-07T12:00:36Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2024-03
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Kazakova, T., Marshinskaya, O., and Notova, S. 2024. Influence of subchronic exposure to manganese carried by female rats during pregnancy on the behavioral and cognitive abilities of their offspring at later stages of postnatal development. Bio. Comm. 69(1): 12–25. https://doi.org/10.21638/spbu03.2024.102
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/spbu03.2024.102
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/45568
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: The study evaluated the effects of prenatal exposure to manganese (Mn)
  on the functional state of offspring at later stages of postnatal development
  (PND). Female rats were treated with MnSO4 · 5H2O in the diet at a dose of
  1433 mg/kg starting 28 days prior to breeding and through gestation. The pregnancy
  proceeded normally, no physical abnormalities were observed. There
  was a lag in physical development of the offspring, which was characterized
  by a later opening of the eyes, the formation of a coat and the eruption of incisors,
  the weight gain was attenuated from PND 0–84. Offspring had hyperactive
  behavior and deterioration in spatial learning and memory. The level of Mn in
  the blood serum and cerebral cortex was higher than the control values by 11
  and 53 % respectively. The acetylcholinesterase level in the serum was higher
  by 47 %. These findings highlight the risk of prenatal exposure to subchronic
  doses of Mn.
metadata.lang: en_GB
metadata.name: dc.description.sponsorship
metadata.value: The present work was prepared
  within the framework of the state task of
  the Federal Research Center of Biological
  Systems and Agrotechnologies of the
  Russian Academy of Sciences (project
  no. FNWZ-2022-0011).
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Biological Сommunications;Volume 69; Issue 1
metadata.lang: -
metadata.name: dc.subject
metadata.value: heavy metals
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: manganese
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: toxicity
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: prenatal influence
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: behavior
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: cognitive abilities
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: acetylcholinesterase
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: biomarker
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Influence of subchronic exposure to manganese carried by female rats during pregnancy on the behavioral and cognitive abilities of their offspring at later stages of postnatal development
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: BioComm_69_1_12-25.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/45568/1/BioComm_69_1_12-25.pdf
resources.format: Adobe PDF
resources.size: 1,32 MB