title: Ageing Acceleration and Disease Onset: Ontogenetic Specificity of Pathogenetic Mechanisms
metadata.name: dc.contributor.author
metadata.value: Riga, D.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Riga, Sorin
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Budisteanu, Magdalena
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Scripnic, Vitalie V.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Budisteanu, Bogdan
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Dionisie, Vlad
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2019-11-26T12:52:15Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2019-11-26T12:52:15Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2019-06
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Riga D., Riga S., Budisteanu M., Budisteanu B., Dionisie V., Scripnic V. V. Ageing Acceleration and Disease Onset: Ontogenetic Specificity of Pathogenetic Mechanisms. Vestnik of Saint Petersburg University. Medicine, 2019, vol. 14, issue 2, pp. 105–122.
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/spbu11.2019.203
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/16649
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: The article which unfortunately happened to be the last poshumous paper published by recently
  deseased Prof. Habil. Dan Riga, MD, PhD, DHc, is devoted to the problem of imperfection
  and vulnerability of the natural genetically determined adaptation mechanisms available
  to human being. All defensive mechanisms encoded in human reactivity are principally imperfect
  and have to cause secondary harm. It means that the very defence is pathogenic, especially
  in chronic situations when the natural cost of adaptation increases to unbearably high
  level. That is central paradigm of the whole science of Pathophysiology. The imperfection and
  secondary pathogenicity of natural defence (autopathokinesis) was emphasized earlier, since
  first coined by August Weismann, for example in works published by L. P. Churilov. This article
  analyses the basic aspects of health and disease under the aforementioned bias, with original
  interpretation of the role of vulnerability and imperfection of human defensive mechanisms
  in chronic repeated stress and within the continuum of physiologic and pathological senescence.
  The principle is illustrated by several examples from the general pathology of typical
  pathological processes and with the correlations to most important geriatric syndromes and
  diseases. According the statements of the authors, the human being has an ontogenetic route,
  from childhood and youth health, through adulthood, towards old age (senescence) and related
  multiple pathology (including dementia). Human vulnerability is extremely complex and
  manifests at different levels: macromolecular, sub-cellular, cellular, tissual, of organs, of biological
  system, with additional specific traits for the central nervous system. Slowly, throughout
  individual ontogenesis, closely related to vulnerability, an etiopathogenic cascade (tetrad) develops: it is entropic, of structures disorganisation and disturbance of their functioning:
  distress wear-and-tear “ageing” poly-pathology. Its dynamics is self-sustained, aggravated, and
  rendered more complex by vicious patho-physiological multiplication circuits.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Vestnik of St Petersburg University. Medicine;Volume 14; Issue 2
metadata.lang: -
metadata.name: dc.subject
metadata.value: ontogenesis
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: sanogenesis
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: distress
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: oxidative stress
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: wear
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: ectropic
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: brain volatility
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: optoptosis
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: telomere
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: telomerase
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: molecular chaperones
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: heat-shoch proteins (HSB)
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: etiopathogenic entropy cascade
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: stressful lifestyles
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Ageing Acceleration and Disease Onset: Ontogenetic Specificity of Pathogenetic Mechanisms
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 105-122.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/16649/1/105-122.pdf
resources.format: Adobe PDF
resources.size: 726,36 kB