title: Catechol-O-methyltransferase polymorphism in women with uterine leiomyoma and adenomyosis
metadata.name: dc.contributor.author
metadata.value: Niauri, Dariko A.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Dzhemlikhanova, Lyailya Kh.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Gzgzyan, Alexandr M.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Osinovskaya, Natalia S.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Gorovaya, Ekaterina A.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Ivashchenko, Tatyana E.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Sultanov, Iskender Yu.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Tkachenko, Antonina N.
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2017-01-27T14:49:20Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2017-01-27T14:49:20Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2016-09
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Dzhemlikhanova L. K., Niauri D. A., Osinovskaya N. S. Catechol-O-methyltransferase polymorphism in women with uterine leiomyoma and adenomyosis. Vestnik of Saint Petersburg University. Series 11. Medicine, 2016, issue 3, pp. 103–110.
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: 10.21638/11701/spbu11.2016.310
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/5965
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: The aim of this research was to study the frequency of polymorphic variants Val158Met (rs4680) of
  catechol-O-methyltransferase (COMT) gene in patients with uterine leiomyoma. A polymerase chain
  reaction was performed to figure out the frequency of polymorphic alleles of COMT gene in 54 patients
  with uterine leiomyoma and 103 women from the general population. It is shown that the presence
  of the genotype G/G of the COMT gene is associated with 2.5 times-increased risk of uterine
  leiomyoma (RR 2,44, Cl95: 1,168-5,103), whereas the genotype A/A is not associated with the development
  of leiomyoma. At the same time, a comparative analysis of the genotypes frequencies of the
  COMT gene polymorphism between groups with different combinations of hyperplastic processes
  of reproductive system (uterine leiomyoma, adenomyosis, hyperplastic processes of endometrium),
  showed no statistically significant differences. Refs 26. Tables 3.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Vestnik of St Petersburg University. Series 11. Medicine;Issue 3
metadata.lang: -
metadata.name: dc.subject
metadata.value: fibroids
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: leiomyoma
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: adenomyosis
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: hyperplastic process of endometrium
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: catechol-o-methyltransferase
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Catechol-O-methyltransferase polymorphism in women with uterine leiomyoma and adenomyosis
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 10-Niauri.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/5965/1/10-Niauri.pdf
resources.format: Adobe PDF
resources.size: 511 kB