title: 3D organization of chicken genome demonstrates evolutionary conservation of topologically associated domains and highlights unique architecture of erythrocytes' chromatin
metadata.name: dc.contributor.author
metadata.value: Fishman, Veniamin
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Battulin, Nariman
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Nuriddinov, Miroslav
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Maslova, Antonina
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Zlotina, Anna
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Strunov, Anton
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Chervyakova, Darya
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Korablev, Alexey
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Serov, Oleg
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Krasikova, Alla
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2018-11-26T19:05:41Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2018-11-26T19:05:41Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2018-11-12
metadata.lang: -
metadata.name: dc.identifier
metadata.value: 10.1093/nar/gky1103
metadata.lang: -
metadata.name: dc.identifier.issn
metadata.value: 10.1093/nar/gky1103
metadata.lang: -
metadata.name: dc.identifier.issn
metadata.value: 10.1093/nar/gky1103
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/15061
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: How chromosomes are folded, spatially organized and regulated in three dimensions inside the cell nucleus are among the longest standing questions in cell biology. Genome-wide chromosome conformation capture (Hi-C) technique allowed identifying and characterizing spatial chromatin compartments in several mammalian species. Here, we present the first genome-wide analysis of chromatin interactions in chicken embryonic fibroblasts (CEF) and adult erythrocytes. We showed that genome of CEF is partitioned into topologically associated domains (TADs), distributed in accordance with gene density, transcriptional activity and CTCF-binding sites. In contrast to mammals, where all examined somatic cell types display relatively similar spatial organization of genome, chicken erythrocytes strongly differ from fibroblasts, showing pronounced A- and B- compartments, absence of typical TADs and formation of long-range chromatin interactions previously observed on mitotic chromosomes. Comparing mammalian and chicken genome architectures, we provide evidence highlighting evolutionary role of chicken TADs and their significance in genome activity and regulation.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: Nucleic Acids Research
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: 3D organization of chicken genome demonstrates evolutionary conservation of topologically associated domains and highlights unique architecture of erythrocytes' chromatin
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: gky1103.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/15061/1/gky1103.pdf
resources.format: Adobe PDF
resources.size: 17,73 MB