title: NMR studies of excluded volume interactions in peptide dendrimers
metadata.name: dc.contributor.author
metadata.value: Sheveleva, Nadezhda N.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Markelov, Denis A.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Vovk, Mikhail A.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Mikhailova, Maria E.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Tarasenko, Irina I.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Neelov, Igor M.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Lähderanta, Erkki
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2019-06-19T17:03:04Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2019-06-19T17:03:04Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2018-06-11
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Sheveleva, N. N., Markelov, D. A., Vovk, M. A., Mikhailova, M. E., Tarasenko, I. I., Neelov, I. M., & Lähderanta, E. (2018). NMR studies of excluded volume interactions in peptide dendrimers. Scientific reports, 8(1), 8916.
metadata.lang: en_GB
metadata.name: dc.identifier.issn
metadata.value: 2045-2322
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/15740
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: Peptide dendrimers are good candidates for diverse biomedical applications due to their biocompatibility and low toxicity. The local orientational mobility of groups with different radial localization inside dendrimers is important characteristic for drug and gene delivery, synthesis of nanoparticles, and other specific purposes. In this paper we focus on the validation of two theoretical assumptions for dendrimers: (i) independence of NMR relaxations on excluded volume effects and (ii) similarity of mobilities of side and terminal segments of dendrimers. For this purpose we study 1H NMR spin-lattice relaxation time, T1H, of two similar peptide dendrimers of the second generation, with and without side fragments in their inner segments. Temperature dependences of 1/T1H in the temperature range from 283 to 343 K were measured for inner and terminal groups of the dendrimers dissolved in deuterated water. We have shown that the 1/T1H temperature dependences of inner groups for both dendrimers (with and without side fragments) practically coincide despite different densities of atoms inside these dendrimers. This result confirms the first theoretical assumption. The second assumption is confirmed by the 1/T1H temperature dependences of terminal groups which are similar for both dendrimers.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: Scientific Reports
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: 8;8916
metadata.lang: -
metadata.name: dc.title
metadata.value: NMR studies of excluded volume interactions in peptide dendrimers
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: Sheveleva_SciRep_2018.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/15740/1/Sheveleva_SciRep_2018.pdf
resources.format: Adobe PDF
resources.description: article text
resources.size: 2,07 MB