title: The development and origins of vertebrate meninges
metadata.name: dc.contributor.author
metadata.value: Batarfi, Munirah
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Valasek, Petr
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Krejci, Eliska
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Huang, Ruijin
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Patel, Ketan
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2017-09-20T11:28:18Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2017-09-20T11:28:18Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2017-06
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Batarfi, M., Valasek, P., Krejci, E., Huang, R., and Patel, K. 2017. The development and origins of vertebrate meninges. Bio. Comm. 62(2): 73–81.
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: 10.21638/11701/spbu03.2017.203
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/7137
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: Meninges comprise three distinct layers, the dura mater, arachnoid, and pia
  mater that surround the brain, spinal cord and some parts of the nerves. Traditionally
  the meninges were believed to serve only as protection for tissues that
  they encase. However recent work shows they have other important functions
  related to development and regulation of the nervous system. Given the importance
  of the meninges, it is surprising that we know very little about their development.
  The embryological origin of the meninges has been debated for over a
  hundred years. Some studies imply that the meninges develop from the neural
  crest, while others suggest that they come from the somites. Here, we investigated
  the temporal development of meninges in birds and mice and found they
  form at comparable stages. We investigated the origin of avian spinal meninges
  using chick/quail cell tracing protocols and found they do not develop from
  the somites as previously thought. We propose that meningeal epithelial blood
  vessels may have been mistaken as meninges and led to an erroneous conclusion
  by previous investigators. We present data that show that avian spinal meninges
  originated from the neural crest supported by data demonstrating that
  they express the neural crest marker HNK1. Finally using the Wnt1-Cre mouse
  we show that trunk meninges of mammals also originate from neural crest.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Biological Communications;Volume 62; Issue 2
metadata.lang: -
metadata.name: dc.subject
metadata.value: еmbryo
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: сhick
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: mouse
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: meninges
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: development
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: The development and origins of vertebrate meninges
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 03-Batarfi.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/7137/1/03-Batarfi.pdf
resources.format: Adobe PDF
resources.size: 4,78 MB