title: Mechanism of antisurdant action of triazin-indole derivative at experimental acoustic trauma
metadata.name: dc.contributor.author
metadata.value: Pastushenkov, Vladimir L.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Kuznecov, Maxim S.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Dvorjanchikov, Vladimir V.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Pastushenkov, Alexander L.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Gabaeva, Madina M.
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2021-08-25T10:15:03Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2021-08-25T10:15:03Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2021-03
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Pastushenkov V. L., Kuznecov M. S., Dvorjanchikov V. V., Pastushenkov A. L., Gabaeva M. M. Mechanism of antisurdant action of triazin-indole derivative at experimental acoustic trauma. Vestnik of Saint Petersburg University. Medicine, 2021, vol. 16, issue 1, pp. 13–19.
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/spbu11.2021.102
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/32932
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: In our research performed using model of acoustic trauma at experimental animals (female
  of hybrids F1 of CBA and C57BL/6 lines) influence of triazin-indole at expression level of
  hypoxia induced factor (HIF) in Corti’s organ was studied at its therapy application. As a reference
  drug cytoflavin was used. Investigated drug in the form of 1 % solution was introduced
  into animals parenterally in dosage 5, 7, 10 mg/kg with 2 hr intervals after acoustic impact.
  Injection of cytoflavin as reference drag was performed in 1.7 ml/kg dosage. Level of HIF
  expression in the drug of Corti’s organ was estimated using immunohistochemical method.
  It was found out that triazin-indole derivative increases HIF expression in Corti’s cells and in
  neurons of spiral ganglion at acoustical traumatic impact depending on drug dosage increase.
  Maximal HIF expression in Corti’s cells and in ganglions were noted at therapeutic dose of the
  drug 10 mg/kg. In control group and in the group with application citoflavin in dose 1.7 ml/kg
  minimal HIF expression was observed. According to obtained results of performed investigation
  the authors concluded that antisurdant property of triazin-indole derivative is realized
  through the influence on HIF metabolism (probably, by blockage of prolyl hydroxylase) and
  enables to consider it as a target molecular during the drug application.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Vestnik of St Petersburg University. Medicine;Volume 16; Issue 1
metadata.lang: -
metadata.name: dc.subject
metadata.value: hypoxia
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: induced fator
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: HIF-1
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: acoustical trauma
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: antihypoxic drugs
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: triasin-indole
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: expression
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: laboratory animals
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: mean cytochemical coefficient
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Mechanism of antisurdant action of triazin-indole derivative at experimental acoustic trauma
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 13-19.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/32932/1/13-19.pdf
resources.format: Adobe PDF
resources.size: 1,04 MB