title: Study of gene expression of the Toll-like receptor system in the forebrain cortex of rat pups with prenatal alcohol exposure and pharmacologic correction with rifampicin
metadata.name: dc.contributor.author
metadata.value: Airapetov, Marat
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Eresko, Sergei
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Ignatova, Polina
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Ganshina, Daria
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Sukhanova, Daria
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Mikhailova, Alexandra
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Lebedev, Andrei
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Bychkov, Evgenii
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Shabanov, Petr
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2024-12-17T11:34:47Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2024-12-17T11:34:47Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2024-09
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Airapetov, M., Eresko, S., Ignatova, P., Ganshina, D., Sukhanova, D., Mikhailova, A., Lebedev, A., Bychkov, E., and Shabanov, P. 2024. Study of gene expression of the Toll-like receptor system in the forebrain cortex of rat pups with prenatal alcohol exposure and pharmacologic correction with rifampicin. Bio. Comm. 69(3): 125–135. https://doi.org/10.21638/spbu03.2024.301
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: 10.21638/spbu03.2024.301
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/48133
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: Ethanol causes changes in the toll-like receptor (TLR) system in the brain promoting
  activation of neuroinflammatory pathways. Alcohol consumption during
  pregnancy induces neuroinflammatory processes in the fetus, which can lead
  to the development of symptoms of fetal alcohol spectrum disorder (FASD).
  Modeling prenatal alcohol exposure in our experiment resulted in changes in
  the expression of TLR system genes (Tlr3, Tlr4, Hmgb1, Trif, cytokine genes) in
  the forebrain cortex of baby rats. The administration of rifampicin (from the
  first to the seventh day of neonatal development) normalized the altered expression
  level of the studied genes. This suggests that rifampicin may prevent
  the development of persistent neuroinflammatory phenomena in the forebrain
  cortex of baby rats.
metadata.lang: en_GB
metadata.name: dc.description.sponsorship
metadata.value: The work was carried out
  within the framework of the State Task
  of the Ministry of Education and Science
  of Russia “Neurobiological mechanisms
  of pathogenesis of socially significant
  diseases and post-traumatic disorders. New
  approaches to the modeling of pathological
  processes and correction of disorders”, code
  FGWG-2024-0015.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Biological Сommunications;Volume 69; Issue 3
metadata.lang: -
metadata.name: dc.subject
metadata.value: brain
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: PAE
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: fetal alcohol spectrum disorder
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: toll-like receptors
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: cytokine
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: rifampicin
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Study of gene expression of the Toll-like receptor system in the forebrain cortex of rat pups with prenatal alcohol exposure and pharmacologic correction with rifampicin
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: Bio-Comm_69_3_125-135.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/48133/1/Bio-Comm_69_3_125-135.pdf
resources.format: Adobe PDF
resources.size: 1,39 MB