title: Current knowledge of genetics of COVID-19
metadata.name: dc.contributor.author
metadata.value: Golota, Aleksandr S.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Vologzhanin, Dmitry A.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Kamilova, Tatyana A.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Makarenko, Stanislav V.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Sсherbak, Sergey G.
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2022-08-12T14:08:53Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2022-08-12T14:08:53Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2021-12
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Vologzhanin D. A., Golota A. S., Kamilova Т. А., Makarenko S. V., Sherbak S. G. Current knowledge of genetics of COVID-19. Vestnik of Saint Petersburg University. Medicine, 2021, vol. 16, issue 4, pp. 255–272.
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/spbu11.2021.404
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/37357
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: The ongoing COVID-19 pandemic, caused by coronavirus SARS-CoV-2, is responsible for a
  reported 456,797,217 cases of COVID-19, and 6,043,094 deaths worldwide as of 12.03.2022.
  Following infection with SARS-CoV-2, COVID-19 clinical presentation ranges from asymptomatic
  or mild (~80 % of infections), to severe disease that typically requires hospitalization
  and assisted respiration. Innate immune responses to viral infection are also a critical determinant
  of disease outcome. Genetic risk factors for COVID-19 are in the early stages of study.
  A number of mutations and polymorphisms have been identified that affect the structure and
  stability of proteins — factors of susceptibility to SARS-COV-2 infection, a predisposition to
  the development of respiratory failure, and the need for intensive care. Most of the identified
  genetic factors are related to the function of the immune system. On the other hand, the genetic
  polymorphism of the virus itself affects the spread and severity of the course of COVID-19.
  The genome of the virus accumulates mutations and evolves towards increasing contagiousness,
  replicative ability, and evasion from the host’s immune system. Genetic determinants
  of infection are potential therapeutic targets. Studying them will provide information for the
  development of drugs and vaccines to combat the pandemic.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Vestnik of St Petersburg University. Medicine;Volume 16; Issue 4
metadata.lang: -
metadata.name: dc.subject
metadata.value: COVID-19
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: coronavirus
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: SARS-COV-2
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: genetic predisposition factors
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: mutation
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: polymorphism
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Current knowledge of genetics of COVID-19
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 04.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/37357/1/04.pdf
resources.format: Adobe PDF
resources.size: 658,71 kB