title: Laboratory predictors of the non-alcoholic fatty liver in the persons with abdominal obesity
metadata.name: dc.contributor.author
metadata.value: Kornoukhova, Lyubov A.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Denisov, Nicholay L.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Emanuel, Vladimir L.
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2019-01-29T10:44:26Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2019-01-29T10:44:26Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2018-12
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Kornoukhova L. A., Denisov N. L., Emanuel V. L. Laboratory predictors of the non-alcoholic fatty liver in the persons with abdominal obesity. Vestnik of Saint Petersburg University. Medicine, 2018, vol. 13, issue 4, pp. 376–388.
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: 10.21638/11701/spbu11.2018.405
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/15353
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: The aim of the study: The study of the metabolic status of 74 clinically healthy patients with
  abdominal obesity was performed to determine the most significant predictors of steatosis.
  Materials and Methods: The study did not include patients with clinical signs of liver pathology,
  manifestations of hypertension, decompensation of atherosclerosis. The diagnosis of
  the non-alcoholic fatty liver was established based on ultrasound examination of the liver, as
  well as on FibroMax and SteatoScreen indices (BioPredictive, France). Defined the following
  indicators: ALT, AST, GGT, total bilirubin, blood glucose, triglycerides, total cholesterol,
  apoB, apoA, HDL, LDL, fasting insulin were measured by standard laboratory methods after
  12-hr fasting. In the course of studies, the following indices are obtained: the relationship of
  TG/ HDL; HOMA-IR according to the formula D. R. Matthews; QUICKI on A. Katz; CARO
  according to the formula F. Caro; Metabolic Index (MI). Lipid Accumulation Product (LAP)
  according to the formulas H. Kahn et al. The Visceral Adiposity Index (VAI) is obtained according
  to the formulas M. C. Amato et al. Results: The interdependence between the presence
  of pathological changes in the liver and early steatosis predictors is determined. The
  optimal parameters for preventive diagnostics were selected and validated. The cutoff values
  for Index of steatosis in >32 % of hepatocytes (predictor HS32), Metabolic index, and Visceral
  adiposity index (VAI) are 0,69 (sensitivity 81 %, specificity 88), 3,0 (sensitivity 76 %, specificity
  78 %), and 3,24 (sensitivity 72 %, specificity 82 %) (p < 0,001, respectively).The areas under the
  ROC curves (95 % CI) for the parameters are 0,910 (0,837–0,958), 0,843 (0,770–0,900), and
  0,784 (0,705–0,851), respectively. The cutoff values for Triglyceride and Total cholesterol are
  2,27 (sensitivity 58 %, specificity 96 %), and 6,4 (sensitivity 54 %, specificity 95 %) (p < 0,001,
  respectively). We suggest that the cutoff values of these simple methods can be applied to
  evaluate hepatic steatosis grade in adults with abdominal obesity.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: ru
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Vestnik of St Petersburg University. Medicine;Volume 13; Issue 4
metadata.lang: -
metadata.name: dc.subject
metadata.value: obesity
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: non-alcoholic fatty liver (NAFL)
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: рreventive medicine
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: biochemical markers
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: prenosological
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Laboratory predictors of the non-alcoholic fatty liver in the persons with abdominal obesity
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 05-Kornoukhova.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/15353/1/05-Kornoukhova.pdf
resources.format: Adobe PDF
resources.size: 662,94 kB