title: S-adenosylmethionine therapy in rheumatic and related autoimmune diseases
metadata.name: dc.contributor.author
metadata.value: de Carvalho, Jozélio Freire
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Churilov, Leonid P.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Lerner, Aaron
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Sobolevskaya, Polina A.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Basina, Alena A.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Gavrilova, Natalia Yu.
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2024-03-27T19:56:17Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2024-03-27T19:56:17Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2023-12
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: de Carvalho J. F., Churilov L. P., Lerner A., Sobolevskaia P. A., Basina А. А., Gavrilova N. Yu. S-adenosylmethionine therapy in rheumatic and related autoimmune diseases. Vestnik of Saint Petersburg University. Medicine, 2023, vol. 18, issue 4, pp. 348–360. https://doi.org/10.21638/spbu11.2023.401
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/spbu11.2023.401
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/45161
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: S-adenosylmethionine has been used to treat neuropsychiatric diseases, including those accompanied
  with depression. These entities often are comorbid with rheumatic and thyroid
  pathology, and in the COVID-19 pandemic and post-pandemic periods, there was a growing
  number of such cases. That’s why the article evaluates the experience and perspectives of S-adenosylmethionine
  therapy in osteoarthritis and a few rheumatic and comorbid thyroid diseases
  (fibromyalgia, systemic sclerosis, gout and autoimmune thyroiditis). PubMed/MEDLINE,
  EMBASE, elibrary.ru and Scielo databases were searched for targeted topic between 1966 and
  2023. 15 articles were depicted to fulfill the inclusion criteria, 13 in Latin and 2 in Cyrillic
  scripts, including 1,499 patients (1,383 in osteoarthritis and 116 in other rheumatic diseases).
  The dosage varied from 200 mg to 1,200 mg/day. The follow-up ranged from 3 weeks to
  24 months. Almost all studies (13/15) showed at least one benefit after S-adenosylmethionine therapy supplementation, including 2 papers documented positive effect in vitro achieved
  upon the cells taken from patients. Most side effects were mild, one study showed borderline
  moderate/severe adverse effects. Only pre-clinical/experimental studies of S-adenosylmethionine
  therapy effects on thyroid regulation were revealed. S-adenosylmethionine is a promising
  and safe element of complex therapy for some rheumatic diseases.
metadata.lang: en_GB
metadata.name: dc.description.sponsorship
metadata.value: The research is supported by Russian Science Foundation (RSF) grant no. 22-15-00113, agreement of
  May 13, 2022.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Vestnik of St Petersburg University. Medicine;Volume 18; Issue 4
metadata.lang: -
metadata.name: dc.subject
metadata.value: S-adenosylmethionine
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: SAMe
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: methylation
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: rheumatic diseases
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: rheumatoid arthritis
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: systemic sclerosis
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: osteoarthritis
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: fibromyalgia
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: thyroid glandsystemic sclerosis
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: osteoarthritis
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: fibromyalgia
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: thyroid gland
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: S-adenosylmethionine therapy in rheumatic and related autoimmune diseases
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 01.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/45161/1/01.pdf
resources.format: Adobe PDF
resources.size: 634 kB