title: Renal oncocytoma in a female patient with rheumatoid arthritis and secondary Sjögren’s syndrome: Non-coincidental link to autoimmunity?
metadata.name: dc.contributor.author
metadata.value: de Carvalho, Jozélio Freire
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Churilov, Leonid P.
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2021-12-15T13:00:20Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2021-12-15T13:00:20Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2021-06
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Carvalho J. F. de, Churilov L. P. Renal oncocytoma in a female patient with rheumatoid arthritis and secondary Sjögren’s syndrome: Non-coincidental link to autoimmunity? Vestnik of Saint Petersburg University. Medicine, 2021, vol. 16, issue 2, pp. 77–84.
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/spbu11.2021.201
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/33943
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: The objective of the article was to describe a female patient with rheumatoid arthritis (RA)
  and secondary Sjögren’s syndrome (SS) who developed a renal oncocytoma and was cured
  by percutaneous cryoablation therapy. A 72-year-old female patient with a long-term history
  of polyarthritis involving her hands, shoulders, knees, and ankles associated with morning
  stiffness and rheumatoid factor of 107 U/mL (nr: <29 U/mL) and anti-CCP of 121 U/mL (nr:
  <5 U/mL). A diagnosis of RA was determined 10 years ago, and prednisone with methotrexate
  were initiated, later changed for leflunomide 20mg/day. In 2014 a diagnosis of secondary SS
  was determined. In April 2014, during a routine abdominal ultrasound, a tumor was found in
  her left kidney. A magnetic resonance imaging confirmed a solid nodule with hypervascularization
  on the left kidney. She was submitted to a percutaneous cryoablation procedure without
  any intercurrence, and it had success. The histopathological analysis demonstrated a renal
  oncocytoma limited to the left kidney. No chemotherapy or radiotherapy was needed. After
  surgery, a flare of RA was noted and was resistant to methotrexate and sulfasalazine. Rituximab
  was then started, and she had an excellent progressive response. Minor thyroid changes
  were registered by ultrasound monitoring and signs of hyperparathyroidism manifested. This
  observation illustrates the first ever described case of a patient with RA and secondary SS who
  developed several years after the RA onset, a renal oncocytoma, and was successfully treated with cryoablation therapy. The possible links between oncocytic cell metaplasia/neoplasia and
  autoimmunity are discussed.
metadata.lang: en_GB
metadata.name: dc.description.sponsorship
metadata.value: The work was supported by the grant of the Government of Russian Federation for state support of
  scientific research carried out under the supervision of leading scientists, agreement 14.W03.31.0009.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Vestnik of St Petersburg University. Medicine;Volume 16; Issue 2
metadata.lang: -
metadata.name: dc.subject
metadata.value: rheumatoid arthritis
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: oncocytoma
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: tumor
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: neoplasia
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: metaplasia
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: dysplasia
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: autoimmunity
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: cancer
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: immunosuppressive drugs
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: Sjögren’s syndrome
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: Hürthle — Askanazy cells
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: Hashimoto’s thyroiditis
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Renal oncocytoma in a female patient with rheumatoid arthritis and secondary Sjögren’s syndrome: Non-coincidental link to autoimmunity?
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 77-84.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/33943/1/77-84.pdf
resources.format: Adobe PDF
resources.size: 590,32 kB