title: Oxidative stress and its role in epilepsy. Literature review
metadata.name: dc.contributor.author
metadata.value: Tibekina, Lyudmila M.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Charyeva, Gulshirin Sh.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Kushnirenko, Yaroslav N.
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2024-09-06T19:29:46Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2024-09-06T19:29:46Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2024-03
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Tibekina L. M., Charyyeva G. Sh., Kushnirenko Ya. N. Oxidative stress and its role in epilepsy. Literature review. Vestnik of Saint Petersburg University. Medicine, 2024, vol. 19, issue 1, pp. 28– 44. https://doi.org/10.21638/spbu11.2024.103 (In Russian)
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/spbu11.2024.103
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/47451
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: The article presents the pathophysiological features of oxidative stress and the state of the
  antioxidant system in patients with epilepsy. The issues of lipid peroxidation, its markers, the
  relationship between oxidative stress, endothelial dysfunction and neuroinflammation, as well
  as pathomorphological changes in brain tissue in temporal lobe epilepsy and features of neuroplastic
  processes in these patients are considered. Epileptic seizures can act as a stressor for
  the body and are accompanied by activation of the hypothalamic-pituitary-adrenal system.
  The role of cortisol in changes in hippocampal plasticity and distant damage to the hippocampus
  is considered as a key link in the pathogenesis of cognitive and mental disorders as a result
  of focal brain lesions. Experimental and clinical data indicate an association between epilepsy
  and endothelial dysfunction. It has been established that epileptic seizures are accompanied
  by a long-term loss of the vasodilating function of the cerebral vascular endothelium, leading
  to a violation of their autoregulation. Data are presented on the possibility of restoring the
  perfusion of the epileptogenic focus during an attack, which allows some authors to consider
  them as a compensatory mechanism associated with improved perfusion of brain tissue and
  the energy status of the cell. The effects of antioxidants in the treatment of epilepsy and the
  role of comorbid disorders in its course are described. An opinion has been expressed about
  the prognostic role of oxidative stress markers in the cerebrospinal fluid in the development
  of pharmacoresistance in epilepsy.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: ru
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Vestnik of St Petersburg University. Medicine;Volume 19; Issue 1
metadata.lang: -
metadata.name: dc.subject
metadata.value: oxidative stress
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: lipid peroxidation
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: antioxidant system
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: epilepsy
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: neuroplasticity
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: endothelial dysfunction
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: neuroinflammation
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: antioxidants
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: comorbidity
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Oxidative stress and its role in epilepsy. Literature review
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 11-1-2024+для+сайта_28-44.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/47451/1/11-1-2024%2b%d0%b4%d0%bb%d1%8f%2b%d1%81%d0%b0%d0%b9%d1%82%d0%b0_28-44.pdf
resources.format: Adobe PDF
resources.size: 674,4 kB