title: Gene polymorphism and professional activity as risk factors for the development of arterial hypertension
metadata.name: dc.contributor.author
metadata.value: Golovanova, Natalya E.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Astratenkova, Irina V.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Lukyanova, Irina Yu.
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2023-08-14T10:46:09Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2023-08-14T10:46:09Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2023-03
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Golovanova N. E., Astratenkova I. V., Lukyanova I. Yu. Gene polymorphism and professional activity as risk factors for the development of arterial hypertension. Vestnik of Saint Petersburg University. Medicine, 2023, vol. 18, issue 1, pp. 4–11. https://doi.org/10.21638/spbu11.2023.101 (In Russian)
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/spbu11.2023.101
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/43760
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: The leading cause of death in the modern world is chronic non-infectious diseases, and the
  leading metabolic risk factor is high blood pressure. At present, the role of reactive oxygen species in the development of arterial hypertension is well known, and the influence of
  epigenetic factors, such as social environment, daily routine, nutrition, in combination
  with genetic predisposition, is an important area of study also. The aim of our study was
  to identify the frequency of occurrence of polymorphic variants of the arterial hypertension
  marker gene angiotensinogen (rs4762) in combination with polymorphisms of the
  genes of enzymes of the antioxidant system: superoxide dismutase 2 (rs4880), and catalase
  (rs1001179) in emergency doctors, suffering from arterial hypertension. 20 patients
  participated in the study in whom the diagnosis of hypertension was established prior to
  inclusion in the study. Deoxyribonucleic acid DNA was isolated from epithelial cells of the
  oral cavity. Genotyping of samples was performed by real-time polymerase chain reaction.
  According to the results of our study, the AGT TT variant was not identified in this group,
  AGT CT was found only in 5 people. In other cases (75 %), the development of the disease
  is not associated with the presence of an unfavorable allele of this gene. At the same time,
  50 % of those examined by us revealed the presence of an unfavorable T allele of the catalase
  gene and 80 % of the T allele of the superoxide dismutase 2 gene. Considering that the
  professional activity of emergency doctors is one of the risk factors for the development of
  arterial hypertension, the presence of a high percentage of unfavorable alleles of antioxidant
  system enzymes in their genomes that we have identified indicates an increase in the
  personal risk of this disease.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: ru
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Vestnik of St Petersburg University. Medicine;Volume 18; Issue 1
metadata.lang: -
metadata.name: dc.subject
metadata.value: arterial hypertension
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: genetic polymorphism
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: angiotensinogen
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: superoxide dismutase
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: catalase
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Gene polymorphism and professional activity as risk factors for the development of arterial hypertension
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 01.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/43760/1/01.pdf
resources.format: Adobe PDF
resources.size: 605,43 kB