title: Transforming growth factor beta 1. Biological role and clinical significance
metadata.name: dc.contributor.author
metadata.value: Mosunova, Olga O.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Dementyeva, Elena A.
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2020-11-20T17:18:40Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2020-11-20T17:18:40Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2020-03
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Mosunova O.O., Dementyeva E.A. Transforming growth factor beta 1. Biological role and clinical significance. Vestnik of Saint Petersburg University. Medicine, 2020, vol. 15, issue 1, pp. 49– 55.
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/spbu11.2020.106
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/20803
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: One of the most important representatives of the cytokine family is the transforming growth
  factor beta 1 (TGF beta 1). The purpose of the review is to study the biological role and clinical
  significance of TGF beta 1. Using PubMed databases, eLIBRARY, Google Scholar, keywords
  “cytokines”, “TGF beta 1” found 25,518 sources, 50 selected for analysis. TGF beta 1 is a polyvalent cytokine first isolated from platelets in the 1990s.TGF beta 1 belongs to the family of
  dimeric polypeptides with a molecular weight of 25 kDa. The gene encoding TGF beta 1 is
  found in humans on chromosome 19. TGF beta 1 has a pleiotropic effect on the proliferation and differentiation of a wide range of cells, and therefore regulates many physiologic and
  pathophysiologic processes: immune response, apoptosis, fibrogenesis, and carcinogenesis.
  TGF beta 1 has an effect on almost all organs and tissues. TGF beta 1 is a key marker that can
  be used in the diagnosis of a number of diseases. It is necessary to further study the role of
  TGF beta 1 in the pathophysiologic mechanisms of various diseases, as well as in the development of approaches to targeted therapy.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Vestnik of St Petersburg University. Medicine;Volume 15; Issue 1
metadata.lang: -
metadata.name: dc.subject
metadata.value: transforming growth factor beta 1
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: TGF beta 1
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: cytokines
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: cell proliferation
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: immune response
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: carcinogenesis
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: fibrogenesis
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Transforming growth factor beta 1. Biological role and clinical significance
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 49-55.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/20803/1/49-55.pdf
resources.format: Adobe PDF
resources.size: 590,02 kB