title: Paradoxical effects of antioxidant action in the photohaemolisis system
metadata.name: dc.contributor.author
metadata.value: Galebskaya, Liudviga V.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Solovtsova, Irina L.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Miroshnikova, Elena B.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Sushkin, Mikhail E.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Razumnyy, Artem V.
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2017-01-27T14:41:22Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2017-01-27T14:41:22Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2016-09
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Galebskaya L. V., Solovtsova I. L., Miroshnikova E. B ., Sushkin M. E., Razumnyy A. V. Paradoxical effects of antioxidant action in the photohaemolisis system. Vestnik of Saint Petersburg University. Series 11. Medicine, 2016, issue 3, pp. 95–102.
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: 10.21638/11701/spbu11.2016.309
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/5964
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: The influence of Mexidol (solution for intravenous administration, “PHARMASOFT Ltd”.) in its therapeutic
  (0,24–3,9 μg/мл) and more high (15,6 μg/мл) concentrations on photo induced lysis (with
  Radachlorin, “RADAPHARMA Ltd”, as a photo sensitizer and a monochrome diode 653 nm as a light
  source) of donor RBC was under study.
  Strong acceleration a photo induced haemolysis was found in Mexidol presence evidencing the
  preparation prooxidant action. The grade of the photo induced haemolysis acceleration was rising
  with the increase of Mexidol concentration up to 3,9 μg/мл. High Mexidol concentration (15,6 μg/мл)
  still remaining prooxidative were less effective than some of therapeutic concentrations. The spectral analysis showed that therapeutic mexidol concentrations (0,24–3,9 μg/мл) didn’t
  change absorption maximum of Radachlorin in its “red” maximum. High Mexidol concentration
  (15,6 μg/мл) caused a hypochromic shift of the “red peak”, and its decrease that is in agreement with
  our data on photo induced haemolysis. Possible mechanisms of Mexidol prooxidant activity in photoinduced
  haemolisis system are discussed. Refs 12. Fig. 1. Tabl. 2.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: ru
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Vestnik of St Petersburg University. Series 11. Medicine;Issue 3
metadata.lang: -
metadata.name: dc.subject
metadata.value: prooxidant
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: antioxidant
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: photo-induced haemolysis
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: photo sensitizer
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: erythrocyte
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Paradoxical effects of antioxidant action in the photohaemolisis system
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 09-Galebskaya.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/5964/1/09-Galebskaya.pdf
resources.format: Adobe PDF
resources.size: 720,3 kB