title: Metabolic disorders and gut microbiota
metadata.name: dc.contributor.author
metadata.value: Kotrova, Anna D.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Shishkin, Alexandr N.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Lukashenko, Maria V.
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2021-03-12T14:12:04Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2021-03-12T14:12:04Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2020-09
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Kotrova A. D., Shishkin A. N., Lukashenko M. V. Metabolic disorders and gut microbiota. Vestnik of Saint Petersburg University. Medicine, 2020, vol. 15, issue 3, pp. 177–183.
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/spbu11.2020.302
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/25423
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: Obesity, type 2 diabetes mellitus, metabolic syndrome are metabolic widespread disorders
  that arise both under the influence of external factors (physical inactivity, high-calorie diet)
  and under the influence of internal factors. The latter includes the intestinal microbiota which
  deserves more and more attention in developing new strategies for the correction of metabolic
  diseases. The discovery of new approaches for the gut microbiota study (metagenomic, metabolomic)
  gives a new insight into the diversity and involvement of intestinal bacteria in the
  metabolic processes of the whole organism. This article are reviewed the mechanisms of the
  gut bacteria impact on lipid and carbohydrate metabolism, the relationship of bacteria species
  and their metabolites with tissue insulin sensitivity, body mass index. Special attention in the
  regulation of tissue insulin sensitivity is paid to the role of short-chain fatty acids and secondary
  bile acids, which are metabolites of gut bacteria. Understanding the influence of human
  microbiota and its metabolites on lipid and carbohydrate metabolism provides the basis for
  the development of new approaches to the prevention and treatment of socially significant
  metabolic diseases such as type 2 diabetes mellitus, obesity, metabolic syndrome.
metadata.lang: en_GB
metadata.name: dc.description.sponsorship
metadata.value: The reported study was funded by RFBR, project number 20-315-90106.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Vestnik of St Petersburg University. Medicine;Volume 15; Issue 3
metadata.lang: -
metadata.name: dc.subject
metadata.value: microbiota
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: metabolic disorders
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: lipopolysaccharide
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: short-chain fatty acids
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: bile acids
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Metabolic disorders and gut microbiota
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 9791-Article Text-30717-1-10-20210222.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/25423/1/9791-Article%20Text-30717-1-10-20210222.pdf
resources.format: Adobe PDF
resources.size: 622,11 kB