title: Osteogenic differentiation: a universal cell program of heterogeneous mesenchymal cells or a similar extracellular matrix mineralizing phenotype?
metadata.name: dc.contributor.author
metadata.value: Lobov, Arseniy
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Malashicheva, Anna
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2022-10-11T11:57:14Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2022-10-11T11:57:14Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2022-03
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Lobov, A. and Malashicheva, A. 2022. Osteogenic differentiation: a universal cell program of heterogeneous mesenchymal cells or a similar extracellular matrix mineralizing phenotype? Bio. Comm. 67(1): 32–48. https://doi.org/10.21638/spbu03.2022.104
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/spbu03.2022.104
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/38263
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: Despite the popularity of mesenchymal stem cells (MSCs), many fundamental
  aspects of their physiology still have not been understood. The information accumulated
  to date argues that MSCs from different sources vary in their differentiation
  potential and, probably, in molecular mechanisms of trilineage
  differentiation. Therefore, this review consists of two parts. Firstly, we focus
  on the data on inter- and intra-source variation of MSCs. We discuss in detail
  MSC variation at the single-cell level and direct omics comparison of MSCs
  from four main tissue sources: bone marrow, adipose tissue, umbilical cord
  and tooth. MSCs from all tissues represent heterogeneous populations in vivo
  with sub-populational structures reflecting their functional role in the tissue.
  After in vitro cultivation MSCs lose their natural heterogeneity, but obtain a
  new one, which might be regarded as a cultivation artifact. Nevertheless, MSCs
  from various sources still keep their functional differences after in vitro cultivation.
  In the second part of the review, we discuss how these differences influence
  molecular mechanisms of osteogenic differentiation. We highlight at least
  one subtype of mesenchymal cells differentiation with matrix mineralization —
  odontoblastic differentiation. We also discuss differences in molecular mechanisms
  of pathological heterotopic osteogenic differentiation of valve interstitial
  and tumor cells, but these assumptions need additional empirical confirmation.
  Finally, we observe differences in osteogenic differentiation molecular
  mechanisms of several MSC types and argue that this differentiation might be
  influenced by the cell context. Nevertheless, bone marrow and adipose MSCs
  seem to undergo osteogenic differentiation similarly, by the same mechanisms.
metadata.lang: en_GB
metadata.name: dc.description.sponsorship
metadata.value: The reported study was funded by
  the Russian Foundation for Basic Research
  (project No. 20-14-50535).
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Biological Сommunications;Volume 67; Issue 1
metadata.lang: -
metadata.name: dc.subject
metadata.value: mesenchymal stem cells
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: osteogenic differentiation
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: MSCs
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: MSC heterogeneity
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: scRNA-seq
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: cell differentiation
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: systems biology
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Osteogenic differentiation: a universal cell program of heterogeneous mesenchymal cells or a similar extracellular matrix mineralizing phenotype?
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 04.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/38263/1/04.pdf
resources.format: Adobe PDF
resources.size: 2,33 MB