title: Pharmacokinetics and tissue distribution of novel platinum containing anticancer agent BP-C1 studied in rabbits using sector field inductively coupled plasma mass spectrometry
metadata.name: dc.contributor.author
metadata.value: Navolotskii, Denis V.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Ivanenko, Natalya B.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Solovyev, Nikolay D.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Fedoros, Elena I.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Panchenko, Andrey V.
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2016-04-07T17:35:43Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2016-04-07T17:35:43Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2015
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Drug Testing and Analysis, Volume 7, Issue 9, 1 September 2015, Pages 737-744
metadata.lang: en_GB
metadata.name: dc.identifier.issn
metadata.value: 1942-7603
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/1942
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: A method of platinum quantification in whole blood samples after microwave digestion using sector field inductively coupled plasma mass spectrometry has been developed. The following analytical figures of merit have been established: limit of detection 1.1 μg/L for blood samples, dynamic range 3.6-200 μg/L, intra-day precision (relative standard deviation, n = 9) did not exceed 5%. Spiked samples were analyzed for method validation. The method was used for pharmacokinetics studies of a novel anti-cancer drug BP-C1, a complex of cis-configured platinum and benzene-poly-carboxylic acids. Main pharmacokinetic parameters (area under curve, maximum concentration, clearance, half-life times for α- and β-phase) were estimated for two dosage forms of BP-C1 0.05 and 0.125 mass %. Pharmacokinetic curves were assessed for single and course administration. Studies were performed using rabbits (n = 6) as a model. BP-C1 was injected intramuscularly. The study established dose proportionality of the tested dosage forms and suggested clinical dosing schedule: 5 days of injections followed by 2 days' break. Platinum tissue distribution was studied in tissue samples collected 20 days after the last injection. Predominant platinum accumulation was observed in kidneys, liver, and muscles near injection site. 'Slow' phase of platinum excretion kinetics may be related to the muscles at the injection site.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: John Wiley and Sons Ltd
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Pharmacokinetics and tissue distribution of novel platinum containing anticancer agent BP-C1 studied in rabbits using sector field inductively coupled plasma mass spectrometry
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: Navolotskii_et_al-2015-Drug_Testing_and_Analysis.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/1942/1/Navolotskii_et_al-2015-Drug_Testing_and_Analysis.pdf
resources.format: Adobe PDF
resources.size: 734,72 kB