title: Microencapsulation containing L. acidophilus and S. boulardii for targeted release in the stomach and small intestine
metadata.name: dc.contributor.author
metadata.value: Ngo, Anh
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Minh, Thao
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Bui, Nhi
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Dam, Xuan
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2024-10-11T17:14:59Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2024-10-11T17:14:59Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2024-06
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Ngo, A., Minh, T., Bui, N., and Dam, X. 2024. Microencapsulation containing L. acidophilus and S. boulardii for targeted release in the stomach and small intestine. Bio. Comm. 69(2): 76–89. https://doi.org/10.21638/spbu03.2024.203
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/spbu03.2024.203
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/47684
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: In this study, a microencapsulation system was developed with a dual-layer
  structure comprising Lactobacillus acidophilus and Saccharomyces boulardii
  to enhance the survival rates of probiotic bacteria during transit through the
  stomach. Alginate and chitosan were identified as key factors influencing the
  shape, moisture content, and the number of encapsulated microorganisms in
  the microcapsules. The optimal concentrations of alginate and chitosan were
  determined to be 0.5 % and 3 %, respectively. The microencapsulated structure
  was clearly visualized through Scanning Electron Microscope images, and Infrared
  spectra confirmed the successful encapsulation. Experimental findings
  revealed that S. boulardii was released directly in the stomach, while L. acidophilus
  was released after a 2-hour delay, coinciding with the arrival of microcapsules
  in the small intestine. Subsequently, we proposed the release kinetics of
  microcapsules in the gastrointestinal tract. Although the viability of both S. boulardii
  and L. acidophilus in the microcapsules exhibited a steady decline over the
  storage period, a notable 109 CFU/g of bacteria persisted even after 120 days.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Biological Сommunications;Volume 69; Issue 2
metadata.lang: -
metadata.name: dc.subject
metadata.value: probiotics
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: L. acidophilus
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: S. boulardii
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: viability
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: release
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Microencapsulation containing L. acidophilus and S. boulardii for targeted release in the stomach and small intestine
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: Bio-Comm_69_2_76-89.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/47684/1/Bio-Comm_69_2_76-89.pdf
resources.format: Adobe PDF
resources.size: 9,39 MB