title: reparing Live Influenza Vaccines against Potential Pandemic Influenza Using Nonpathogenic Avian Influenza Viruses and Cold-Adapted Master Donor Strain
metadata.name: dc.contributor.author
metadata.value: Desheva, Yulia
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2018-09-21T20:04:28Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2018-09-21T20:04:28Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2018-09-19
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/14946
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: As part of an influenza pandemic preparedness program, the WHO analyzes a range of
  potentially pandemic influenza viruses for appropriate vaccines development. Several
  vaccine candidates were prepared using classical genetic reassortment, with the coldadapted
  A/Leningrad/134/17/57(H2N2) (Len/17) master donor strain (MDS) which is
  licensed in the Russia for the live influenza vaccine (LAIV) strains type A production for
  adults and children. The nonpathogenic avian viruses of different subtypes were used
  for reassortant vaccine strains preparation. All vaccine candidates demonstrated a high
  reproductive capacity and cold-adapted (ca-) phenotype in chick embryos. In mice, the
  LAIV of H5N2, H7N3, and H9N2 subtypes provided protection against infection with
  distant influenza viruses. The immunogenicity and protective efficacy of H7N3 LAIV
  was also demonstrated in ferrets. The H5N2 and H7N3 vaccine candidates demonstrated
  the inability to reproduce in chickens, which confirms the safety of their use in areas
  with highly developed agriculture. When tested in clinical trials, vaccine strains of H5N2
  and H7N3 subtypes induce the conversions of antibodies homologous and antigenically
  distant variants. The use of LAIV can be effective against highly pathogenic influenza
  viruses even in the case of in
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: InTech
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: reparing Live Influenza Vaccines against Potential Pandemic Influenza Using Nonpathogenic Avian Influenza Viruses and Cold-Adapted Master Donor Strain
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Book chapter
metadata.lang: en_GB
resources.filename: 03_08_desheva_en1.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/14946/1/03_08_desheva_en1.pdf
resources.format: Adobe PDF
resources.size: 2,64 MB