title: Rate of spontaneous polyploidization in haploid yeast Saccharomyces cerevisiae
metadata.name: dc.contributor.author
metadata.value: Andreychuk, Yulia
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Zhuk, Anna
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Tarakhovskaya, Elena
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Inge-Vechtomov, Sergei
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Stepchenkova, Elena
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2022-10-11T13:10:55Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2022-10-11T13:10:55Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2022-06
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Andreychuk,Yu., Zhuk, A., Tarakhovskaya, E., Inge-Vechtomov, S., and Stepchenkova, E. 2022. Rate of spontaneous polyploidization in haploid yeast Saccharomyces cerevisiae. Bio. Comm. 67(2): 88–96. https://doi.org/10.21638/spbu03.2022.202
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/spbu03.2022.202
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/38268
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: Polyploidization is involved in a variety of biological processes. It is one of the
  principal mechanisms of new species formation since it provides material for
  gene diversification and subsequent selection. Multiple cases of polyploidization
  were registered in different branches of the evolutionary tree of eukaryotes.
  Besides its role in evolution, polyploidization affects gene expression in
  living cells: pathological genome duplications often happen in cancer cells. The
  mechanisms and consequences of polyploidization are being studied extensively.
  However, quantitative determination of the polyploidization rate is challenging
  due to its low frequency and the absence of selective genetic markers
  that would phenotypically distinguish between haploids and polyploids. Our
  work describes a robust and straightforward method for discriminating haploid
  and polyploid states in the yeast Saccharomyces cerevisiae, a model organism
  for studying different aspects of polyploidization. The measurement of polyploidization
  rate showed that in yeast cells this process is mainly caused by
  autodiploidization rather than mating-type switching followed by hybridization.
metadata.lang: en_GB
metadata.name: dc.description.sponsorship
metadata.value: The reported study was funded
  by the Russian Foundation for Basic
  Research according to the research project
  No. 20-34-90040. AZ was supported by
  the Government of the Russian Federation
  through the ITMO Fellowship and
  Professorship Program.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Biological Сommunications;Volume 67; Issue 2
metadata.lang: -
metadata.name: dc.subject
metadata.value: Saccharomyces cerevisiae
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: polyploidization
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: haploid
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: diploid
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: wholegenome duplication
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Rate of spontaneous polyploidization in haploid yeast Saccharomyces cerevisiae
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 02.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/38268/1/02.pdf
resources.format: Adobe PDF
resources.size: 1,28 MB