title: The digenean complex life cycle: phylostratigraphy analysis of the molecular signatures
metadata.name: dc.contributor.author
metadata.value: Nesterenko, Maksim
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Shchenkov, Sergei
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Denisova, Sofia
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Starunov, Viktor
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2022-10-11T12:15:03Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2022-10-11T12:15:03Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2022-06
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Nesterenko, M., Shchenkov, S., Denisova, S., and Starunov, V. 2022. The digenean complex life cycle: phylostratigraphy analysis of the molecular signatures. Bio. Comm. 67(2): 65–87. https://doi.org/10.21638/spbu03.2022.201
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/spbu03.2022.201
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/38267
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: The parasitic flatworms from Digenea group have been the object of numerous
  in-depth studies for several centuries. The question of the evolutionary origin
  and transformation of the digenean complex life cycle remains relevant and
  open due to the biodiversity of these parasites and the absence of fossil records.
  However, modern technologies and analysis methods allow to get closer
  to understanding the molecular basis of both the realization of the cycle and its
  complication. In the present study, we have applied phylostratigraphy and evolutionary
  transcriptomics approaches to the available digenean genomic and
  transcriptomic data and built ancestral genomes models. The comparison results
  of Platyhelminthes and Digenea ancestor genome models made it possible
  to identify which genes were gained and duplicated in the possible genome
  of digenean ancestor. Based on the bioprocesses enrichment analysis results,
  we assumed that the change in the regulation of many processes, including
  embryogenesis, served as a basis for the complication of the ancestor life cycle.
  The evolutionary transcriptomics results obtained revealed the “youngest” and
  “oldest” life cycle stages of Fasciola gigantica, F. hepatica, Psilotrema simillimum,
  Schistosoma mansoni, Trichobilharzia regenti, and T. szidati. Our results can serve
  as a basis for a more in-depth study of the molecular signatures of life cycle
  stages and the evolution transformation of individual organ systems and stagespecific
  traits.
metadata.lang: en_GB
metadata.name: dc.description.sponsorship
metadata.value: The research was funded by
  the Russian Foundation for Basic Research,
  project No. 19-34-90111 and by the State
  research project No. 1021051703357-3.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Biological Сommunications;Volume 67; Issue 2
metadata.lang: -
metadata.name: dc.subject
metadata.value: flatworms
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: Digenea
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: complex life cycle
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: molecular signature
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: phylostratigraphy
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: evolutionary transcriptomics
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: The digenean complex life cycle: phylostratigraphy analysis of the molecular signatures
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 01.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/38267/1/01.pdf
resources.format: Adobe PDF
resources.size: 10,02 MB