title: Publication-based analysis of miR-210 dependent biomarkers of pre-eclampsia
metadata.name: dc.contributor.author
metadata.value: Tkachenko, Alexander
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Illarionov, Roman
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Vashukova, Elena
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Glotov, Andrei
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2020-09-04T22:00:29Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2020-09-04T22:00:29Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2020-06
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Tkachenko, A., Illarionov, R., Vashukova, E., and Glotov, A. 2020. Publication-based analysis of miR-210 dependent biomarkers of pre-eclampsia. Bio. Comm. 65(2): 163–177.
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi. org/10.21638/spbu03.2020.203
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/19217
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: MicroRNAs (miRNAs) are potential biomarkers of most pregnancy complications. In recent years, miR-210 has been shown as one of the main biomarkers, detected at different stages of pregnancy and associated with various diseases, including pre-eclampsia (PE). However, miR-210 is not reported as a marker of PE in about half of the studies. We filtered available published RNA-seq data and miRNAs associated with PE, including or excluding miR-210, obtained from the PregMiR database. For further analysis we only considered miRNAs appearing in at least four different studies. We observed that miR-152, miR-1 and miR-193b were only detected in studies with a changed miR-210 level, whereas miR-27a, miR-29a, miR-130a and miR-519b were detected in studies without miRNA-210 differential expression. Common biomarkers of PE are miR-182, miR-126, miR-155, miR-181a, miR-18a, miR-195, miR-21, miR-223, miR-335, miR517c, miR-518b, miR-518e and let-7f. Based on the obtained data and taking into account the direction of differential miRNA expression, it can be assumed that the most likely mechanisms of PE development in the early pregnancy stage are either upregulation of miR-210, miR-152, miR-518b and downregulation of miR-126; or upregulation of miR-126 and downregulation of miR-182 and miR518b. Late stages of PE are determined by miR-210, miR-152, miR-518b, miR-21, miR-155, miR-181a, miR-182, miR-193b-3p, miR-517c, miR-518e (upregulation) and miR-126, miR-18a, miR-195, miR-223, let-7f (downregulation); or miR-27a, miR-29a, miR-130a and miR-519d, miR-517c, miR-518e miR-155, miR-126, miR181a, miR-195 (upregulation) and miR-223, miR-18a, miR-182 (downregulation). The presented results allow speculation about the influence of certain miRNAs on PE development in the context of the presence or absence of miR-210 differential expression, but additional experimental studies are required to evaluate the findings.
metadata.lang: en_GB
metadata.name: dc.description.sponsorship
metadata.value: This study was financially supported by Russian Scientific Foundation, grant № 19-75-20033 (research, bioinformatics) and D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, project № 0558-2017-0056 (support of PregMiR database).
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Biological Сommunications;Volume 65; Issue 2
metadata.lang: -
metadata.name: dc.subject
metadata.value: microRNA
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: pregnancy complications
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: miR-210
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: pre-eclampsia
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: bioinformatics analysis
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Publication-based analysis of miR-210 dependent biomarkers of pre-eclampsia
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 163-177.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/19217/1/163-177.pdf
resources.format: Adobe PDF
resources.size: 2,33 MB