title: Heterogeneity of the barrier properties of the colon in rat
metadata.name: dc.contributor.author
metadata.value: Bekusova, Viktoria
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Fatyykhov, Ilyas
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Amasheh, Salah
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Markov, Alexander
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2021-08-20T20:09:20Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2021-08-20T20:09:20Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2021-06
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Bekusova, V., Fatyykhov, I., Amasheh, S., and Markov, A. 2021. Heterogeneity of the barrier properties of the colon in rat. Bio. Comm. 66(2): 160–170.
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/spbu03.2021.207
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/32818
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: The incidence of colorectal cancer in different parts of the large intestine is not
  the same, as tumors more often appear in the distal part of the colon compared
  to the proximal one. The purpose of this study was to investigate heterogeneity
  of the barrier properties of the colon and clarify the effects of Prostaglandin
  E2 and interleukin-1beta on its different parts. An in-depth analysis of short circuit
  current, transepithelial electrical resistance and paracellular permeability
  for sodium fluorescein in Ussing chambers showed that the proximal part of
  the colon was less permeable compared to the distal one and the substances
  had different effects on the parameters of permeability in different parts of the
  colon. We suppose that heterogeneity of the barrier properties of the colon and
  various effects of their regulation by local molecular agents may determine different
  incidence of pathologies in the colon.
metadata.lang: en_GB
metadata.name: dc.description.sponsorship
metadata.value: This research was sponsored by
  the Grant of RFFI (20-04-01050).
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Biological Сommunications;Volume 66; Issue 2
metadata.lang: -
metadata.name: dc.subject
metadata.value: rat
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: colon
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: heterogeneity
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: prostaglandin E2
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: interleukin-1beta
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: Ussing chamber
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: short circuit current
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: transepithelial electrical resistance
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: intestinal permeability
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: barrier properties
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Heterogeneity of the barrier properties of the colon in rat
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 160-170.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/32818/1/160-170.pdf
resources.format: Adobe PDF
resources.size: 1,55 MB