title: The influence of the ionic strength of the medium and the nature of counterions on the interaction of DNA molecule with derivatives of actinocin and isoquinoline
metadata.name: dc.contributor.author
metadata.value: Moroshkina, Evgenia
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Osinnikova, Daria
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Travkina, Veronika
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2017-03-20T15:24:01Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2017-03-20T15:24:01Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2016-12
metadata.lang: -
metadata.name: dc.identifier.other
metadata.value: 10.21638/11701/spbu04.2016.404
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/6105
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: In this work the interaction of the DNA molecule with derivatives of actinocin and isoquinoline
  was studied by spectral, calorimetric and hydrodynamic methods under different ionic strength of
  the medium. All investigated compounds formed reversible equilibrium complexes with the DNA
  molecule. When μ = 0.1, the flat heterocyclic chromophores of the compounds either intercalated
  in the DNA double helix or located in one of the grooves, depending on the length of the alkyl
  chain linking the chromophore with protonated groups of actinocin derivatives. With the decrease
  of ionic strength there was an increase in affinity of all investigated compounds to DNA and second
  mode of interaction, leading to the formation of intercalated dimers, added to the intercalation
  binding. Not intercalating ligands (in a high ionic strength) changed the mode of binding and
  behaved like intercalators, causing an increase in contour length of the macromolecule, while the
  ionic strength decreased to 0.001. Refs 21. Figs 5. Tables 3.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: ru
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Vestnik of St Petersburg University. Series 4. Physics. Chemistry;Vol. 3 (61); Issue 4
metadata.lang: -
metadata.name: dc.subject
metadata.value: interaction
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: DNA
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: isoquinoline derivatives
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: actinocin derivatives
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: calorimetry
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: spectrophotometry
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: viscometry
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: intercalation
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: The influence of the ionic strength of the medium and the nature of counterions on the interaction of DNA molecule with derivatives of actinocin and isoquinoline
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 04-Moroshkina.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/6105/1/04-Moroshkina.pdf
resources.format: Adobe PDF
resources.size: 581,78 kB