title: The influence of adrenaline on contractility and excitability of myocardium of rat right ventricle depending on phases of the estrous cycle and pregnancy
metadata.name: dc.contributor.author
metadata.value: Korotaeva, Yuliya V.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Nozdrachev, Alexander D.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Tsirkin, Victor I.
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2017-01-27T15:38:35Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2017-01-27T15:38:35Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2016-12
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Korotaeva Ju. V., Nozdrachov A. D., Tsirkin V. I. The influence of adrenaline on contractility and excitability of myocardium of rat right ventricle depending on phases of the estrous cycle and pregnancy. Vestnik SPbSU. Series 3. Biology, 2016, issue 4, pp. 76–98.
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: 10.21638/11701/spbu03.2016.406
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/5976
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: Investigated the contractile activity of 34 myocardium strips of right ventricular of 17 nonpregnant
  rats, including with estrogen (9) and progesterone (8) background, and 17 pregnant rats — at the early
  (5–10 days; n = 7), middle (11–18 days; n = 7) and late (19–21 days; n = 3) stages. Contractions caused
  by electrostimuls (5 ms, 20 B, 1 Hz), and their registration was performed using the force transducer.
  Adrenoreactivity of strips were evaluated by the pattern of inotropic and batmotropic effects of adrenaline
  (10-9–10-5 g/ml). It has been established that contractility of myocardium is not changed during
  the estrous cycle. In pregnancy, it does not increase, and even decreases, which is typical for middle
  and late stages. Adrenoreactivity of myocardium, according to the inotropic effect of adrenaline, did
  not depend on the phase of the estrous cycle (PhEC), but depended on the presence of pregnancy — in
  early stages it remained relatively high, and in the middle and late stages — decreased. Excitability of
  intactmyocardium did not depend on PhEC and the presence of pregnancy. Adrenaline showed positive
  batmotropic effect. Its expression was dependent on the PhEC (it decreases with the dominance of
  progesterone background) and the presence of pregnancy (in early stage it increases, and in the middle
  and late stages — it decreases). It is assumed that changes of adrenoreactivity of the myocardium of
  the rat right ventricle during pregnancy are due by increasing of the expression of alpha1-, beta2- and
  beta3-adrenoceptors. Refs 58. Figs 5. Table 1.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: ru
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Vestnik of St Petersburg University. Series 3. Biology;Issue 4
metadata.lang: -
metadata.name: dc.subject
metadata.value: rat myocardium
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: right ventricle
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: contractility
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: electroexcitability
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: estrous cycle
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: pregnancy
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: The influence of adrenaline on contractility and excitability of myocardium of rat right ventricle depending on phases of the estrous cycle and pregnancy
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 06-Korotaeva.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/5976/1/06-Korotaeva.pdf
resources.format: Adobe PDF
resources.size: 442,54 kB