title: Effect of diamminedichloroplatinum(II) on dimerization of bovine serum albumin in solution
metadata.name: dc.contributor.author
metadata.value: Chikhirzhina, Elena V.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Belaya, Irina A.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Baranova, Yuliia G.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Polyanichko, Alexander M.
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2017-07-04T15:33:40Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2017-07-04T15:33:40Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2017-03
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Chikhirzina E. V., Belaya I. A., Baranova Yu. G., Polyanichko A. M. Effect of diamminedichloroplatinum(II) on dimerization of bovine serum albumin in solution. Vestnik SPbSU. Physics and Chemistry. 2017, vol. 4 (62), issue 1, pp. 46–58.
metadata.lang: en_GB
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/6655
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: Complexes of cis- and trans-isomers of diamminedichloroplatinum(II) (DDP) with bovine serum
  albumin (BSA) were studied using electrophoretic analysis and FTIR spectroscopy. We have
  demonstrated that intermolecular protein complexes were formed in solutions containing excessive
  amount of platinum and BSA in concentrations close to the physiological one. Analysis of the IR
  spectra revealed that the interaction of BSA with DDP is accompanied by decreasing α-helical
  content of the BSA from 65 to 55% in the complexes with cis-DDP and to 48% in the case of
  trans-DDP; while the amount of β-structures in the protein increases from 15–20 to 20–30% in
  the complexes with cis-DDP and to 35–40% in the complexes with trans-DDP. Based on the data obtained we suggest, that the binding of DDP induces the changes in the protein secondary
  structure, which stimulates dimerization of the BSA in solution. Refs 47. Figs 3. Tables 1.
metadata.lang: en_GB
metadata.name: dc.description.sponsorship
metadata.value: Работа выполнена при финансовой поддержке Российского фонда фундаментальных исследований
  (проекты 15-04-06993, 15-08-06876).
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: ru
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Vestnik of St Petersburg University. Physics and Chemistry;Volume 4 (62); Issue 1
metadata.lang: -
metadata.name: dc.subject
metadata.value: BSA
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: DDP
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: FTIR spectroscopy
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Effect of diamminedichloroplatinum(II) on dimerization of bovine serum albumin in solution
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 07-Chikhirzhina.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/6655/1/07-Chikhirzhina.pdf
resources.format: Adobe PDF
resources.size: 605,08 kB