title: Determination of N7-[2-[(2-hydroxyethyl)thio]-ethyl]guanine in rat’s urine as biomarker of exposure of sulfur mustard
metadata.name: dc.contributor.author
metadata.value: Orlova, O. I.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Karakashev, G. V.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Shmurak, V. I.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Abzianidze, V. V.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Savelieva, E. I.
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2017-10-28T15:20:42Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2017-10-28T15:20:42Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2017-09
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Orlova O. I., KarakashevG.V., ShmurakV. I., AbzianidzeV.V., Savelieva E. I. Determination of N7-[2-[(2-hydroxyethyl)thio]-ethyl]guanine in rat’s urine as biomarker of exposure of sulfur mustard. Vestnik SPbSU. Physics and Chemistry. 2017. Vol. 4 (62), iss. 3. P. 313–325.
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: 10.21638/11701/spbu04.2017.306
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/8631
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: A method for the determination of the sulfur mustard (SM) exposure biomarker-N7-[2-[(2-hydroxyethyl)
  thio]-ethyl]guanine (N7-HETEG) byhigh-performance liquid chromatography-positive
  electrospray tandem mass spectrometry (HPLC-ESI-MS/MS) was developed. An analytical standard
  of N7-HETEG was synthesized and purified (  90%). The limit of detection of the developed
  method is1 ng/mL. The method was linearly calibrated from 1 ng/mL to 100 ng/mL.The method
  was further applied for the quantifications of N7-HETEG in rat urine exposed of SM in vivo at
  dosage of 2 mg/kg. Refs 13. Figs 10. Tables 1.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: ru
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Vestnik of St Petersburg University. Physics and Chemistry;Vol. 4 (62); Issue 3
metadata.lang: -
metadata.name: dc.subject
metadata.value: sulfurmustard
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: biomedical samples
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: biomarker
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: metabolite
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: adduct
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: DNA
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: highperformance liquid chromatography
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Determination of N7-[2-[(2-hydroxyethyl)thio]-ethyl]guanine in rat’s urine as biomarker of exposure of sulfur mustard
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 06-Orlova.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/8631/1/06-Orlova.pdf
resources.format: Adobe PDF
resources.size: 504,73 kB