title: Pharmacoresistance in epilepsy and ways for overcoming it (literature review)
metadata.name: dc.contributor.author
metadata.value: Charyyeva, Gulshirin
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Tibekina, Liudmila M.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Subbotina, Olga P.
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2021-03-12T14:16:10Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2021-03-12T14:16:10Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2020-09
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Charyyeva G., Tibekina L. M., Subbotina O. P. Pharmacoresistance in epilepsy and ways for overcoming it (literature review). Vestnik of Saint Petersburg University. Medicine, 2020, vol. 15, issue 3, pp. 184–197.
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/spbu11.2020.303
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/25424
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: Epilepsy is the most taking place disease of the human nervous system. Despite the fact that
  we are continuously introducing new medicines into therapy of this illness we still are failing
  to take control over seizures in 1/3 cases. Persisting seizures gain considerable influence
  on patients’ living standard and within children audience cause delays in person maturity.
  Given article shows deep analysis of the last years researches which gave background to discover
  main mechanisms of pharmacoresistance. The issues of pathophysiological features of
  medicine resistance and reasons of false diagnostics are as well discussed. Authors highlighted
  few pathologic conditions where applied differential diagnostics allowed to avoid diagnostical
  mistakes. True definition of the certain seizures features according to the up to date classification
  makes it possible for clinical staff to prescribe correct anticonvulsant therapy, so far
  diminishing the risk of pseudo resistance outcome of disease. The article introduces criteria
  of natural resistance which if being recognized allows to perform dew time surgical treatment
  and therefore cuts seizures in most of the cases.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Vestnik of St Petersburg University. Medicine;Volume 15; Issue 3
metadata.lang: -
metadata.name: dc.subject
metadata.value: epilepsy
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: pharmacoresistance
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: classification
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: comorbidity
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: differential diagnosis
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: treatment
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Pharmacoresistance in epilepsy and ways for overcoming it (literature review)
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 9973-Article Text-30718-1-10-20210222.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/25424/1/9973-Article%20Text-30718-1-10-20210222.pdf
resources.format: Adobe PDF
resources.size: 662,04 kB