title: Rheumatoid arthritis associated with Rendu — Osler — Weber disease: Second description
metadata.name: dc.contributor.author
metadata.value: de Carvalho, Jozélio Freire
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Maia Rodrigues, Carlos Ewerton
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: de Freitas Zerbini, Cristiano Augusto
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Churilov, Leonid P.
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2022-03-09T19:53:32Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2022-03-09T19:53:32Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2021-09
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Carvalho J. F. de, Maia Rodrigues C. E., Freitas Zerbini C. A. de, Churilov L. P. Rheumatoid arthritis associated with Rendu — Osler — Weber disease: Second description. Vestnik of Saint Petersburg University. Medicine, 2021, vol. 16, issue 3, pp. 147–152.
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/spbu11.2021.301
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/35578
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: The article presents second ever published description of rheumatoid arthritis case co-morbid
  with Rendu — Osler — Weber disease (hereditary hemorrhagic teleangiectasia) in a 63-yearsold
  female patient. The aim is describing the first case report of a patient who after a confirmed
  hereditary hemorrhagic teleangiectasia diagnosis developed rheumatoid arthritis one
  year later. Historical data and brief pathophysiological characteristic of both diseases and their
  possible intermingle are included: (i) mutant genes in hereditary hemorrhagic teleangiectasia
  all encode proteins involved in the TGF-beta signaling pathway, and increased plasma
  levels of TGF-beta-1 and vascular endothelial growth factor have been seen in such patients;
  (ii) TGF-beta plays a role in the development of synovial cell proliferation, inflammation, and
  angiogenesis in rheumatoid arthritis; (iii) TGF-β regulates thymic T-cell selection, inhibits
  cytotoxic T lymphocyte (CTL), Th1-, and Th2-cell differentiation while promoting peripheral Treg-, Th17-, Th9-, and Tfh-cell generation, and T-cell tissue residence in response to immune
  challenges, all essential for pathogenesis of rheumatoid arthriitis. The defect in its reception
  as well as its compensatory increased blood content theoretically can alter autoimmunity thus
  facilitating in Rendu — Osler — Weber disease patients the development of systemic autoimmune
  diseases.
metadata.lang: en_GB
metadata.name: dc.description.sponsorship
metadata.value: Contribution of L. P. Churilov was supported by the grant of the Government of Russian Federation
  for state support of scientific research carried out under the supervision of leading scientists, agreement
  14.W03.31.0009.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Vestnik of St Petersburg University. Medicine;Volume 16; Issue 3
metadata.lang: -
metadata.name: dc.subject
metadata.value: rheumatoid arthritis
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: Rendu — Osler — Weber disease
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: hereditary hemorrhagic telangiectasia
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Rheumatoid arthritis associated with Rendu — Osler — Weber disease: Second description
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 147-152.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/35578/1/147-152.pdf
resources.format: Adobe PDF
resources.size: 928,18 kB