title: Problems of allogenic hematopoietic stem cell transplantation
metadata.name: dc.contributor.author
metadata.value: Shikina, Irina B.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Litvinov, Ivan V.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Babchenko, Victoria S.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Gerova, Olga A.
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2024-03-27T19:40:05Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2024-03-27T19:40:05Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2023-09
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Shikina I. B., Litvinov I. V., Babchenko V. S., Gerova O. A. Problems of allogenic hematopoietic stem cell transplantation. Vestnik of Saint Petersburg University. Medicine, 2023, vol. 18, issue 3, pp. 304–319. https://doi.org/10.21638/spbu11.2023.306 (In Russian)
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/spbu11.2023.306
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/45157
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment for
  many malignant and non-malignant diseases of the blood system. With an existing need of
  five thousand HSCT per year, about two thousand are performed, therefore, not all those in
  need receive this type of treatment. The purpose of the study is to study the main problems
  of allogeneic hematopoietic stem cell transplantation, to identify risk factors, frequency of
  occurrence and impact on the outcome of allo-HSCT of key post-transplant complications.
  A large number of nationalities and ethnic groups live in the country, characterized by a
  unique distribution and frequency of HLA alleles, which led to the formation of a specific
  allelic polymorphism of HLA genes, characteristic only for residents of Russia. In this regard,
  about 25 % of patients do not have a compatible donor in the world. Graft failure is a group
  of complications characterized by two- or three-lineage cytopenia in combination with bone
  marrow hypo-/aplasia and is a major cause that impairs patients short-term survival rates
  after allo-HSCT and affects an average of 40 % of all recipients. The study confirms the need
  to replenish the Federal Register with new hematopoietic stem cell (HSC) donors, which
  will increase the likelihood of finding a compatible HSC donor for the recipient with a nondisseminated
  HLA genotype.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: ru
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Vestnik of St Petersburg University. Medicine;Volume 18; Issue 3
metadata.lang: -
metadata.name: dc.subject
metadata.value: hematopoietic stem cell transplantation
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: polymorphism
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: HLA-alleles
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: graft failure
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: graft-versus-host disease
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: infectious complications
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: donor
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: recipient
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: survival
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Problems of allogenic hematopoietic stem cell transplantation
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 06.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/45157/1/06.pdf
resources.format: Adobe PDF
resources.size: 889,93 kB