title: Comparison of carboplatin and cisplatin effects on DNA structure in solution
metadata.name: dc.contributor.author
metadata.value: Alekseev, Georgy V.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Kasyanenko, Nina A.
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2018-04-26T08:52:42Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2018-04-26T08:52:42Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2018-03
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Alekseev G. V., Kasyanenko N. A. Comparison of carboplatin and cisplatin effects on DNA structure in solution. Vestnik SPbSU. Physics and Chemistry. 2018. Vol. 5 (63), iss. 1. P. 4–12.
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: 10.21638/11701/spbu04.2018.101
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/9485
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: The formation of complexes of high molecular thymus DNA with coordination compounds of platinum(
  II) cisplatin and carboplatin has been examined. The absorption spectra, circular dichroism
  spectra, DNA melting and change in reduced viscosity of DNA solutions containing different concentrations
  of platinum compounds have been analyzed. It was shown that DNA interacts with cisplatin and carboplatin in a solution containing 0.005M NaCl. The nitrogenous bases of macromolecules
  participate in binding. Spectral changes of DNA and the dependence of the reduced
  viscosity of DNA solutions on the concentration of platinum compounds show similar features in
  complex formation when using cisplatin and carboplatin, but at the same time they also indicate
  differences in the influence of cisplatin and carboplatin on DNA structure. Apparently, unlike the
  interchain cross-linking formed by cisplatin, carboplatin binds to a single DNA strand.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: ru
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Vestnik of St Petersburg University. Physics and Chemistry;Volume 5(63); Issue 1
metadata.lang: -
metadata.name: dc.subject
metadata.value: DNA
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: platinum coordination compounds
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: cisplatin
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: carboplatin
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: complex formation in a solution
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: absorption and circular dichroism spectra
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: DNA melting
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: viscometry
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Comparison of carboplatin and cisplatin effects on DNA structure in solution
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 01-Alekseev.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/9485/1/01-Alekseev.pdf
resources.format: Adobe PDF
resources.size: 537,02 kB