title: Autoimmune markers in prognosis of Assisted Reproductive Technology efficiency
metadata.name: dc.contributor.author
metadata.value: Safarian, Galina K.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Dzhemlikhanova, Lyailya Kh.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Kogan, Igor Yu.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Niauri, Darico A.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Bespalova, Olesya N.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Gzgzyan, Alexandr M.
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2023-06-20T14:11:28Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2023-06-20T14:11:28Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2022-12
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Safarian G.Kh., Dzemlikhanova L.Kh., Kogan  I.Yu., Niauri  D.А., Bespalova  O.N., Gzgzyan А.M. Autoimmune markers in prognosis of Assisted Reproductive Technology efficiency.  Vestnik of Saint Petersburg University. Medicine, 2022, vol. 17, issue 4, pp. 238–253.  https://doi.org/10.21638/spbu11.2022.401 (In Russian)
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/spbu11.2022.401
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/41627
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: According to reports, the efficiency of IVF/ICSI protocols is decreased in antithyroid antibodypositive patients as opposed to antibody negatives. However, there are opposite data indicating the absence of the antibody’s impact on the outcome of infertility treatment with assisted reproductive technologies. The prospective study enrolled 90 patients with infertility undergoing treatment with assisted reproductive technologies. The follicular fluid obtained on the day of oocyte retrieval was evaluated for antithyroid peroxidase and antithyroglobulin antibodies using commercial ELISA kits. The main group (n = 45) included women with verified autoimmune thyroiditis and measurable serum and follicular fluid levels of antithyroid antibodies. The comparison group was represented by 45 women without autoimmune thyroiditis. A reliably lower ovarian reserve parameters was noted in the study group relatively to the comparison group. It has been established that follicular fluid AT-TPO levels are negatively associated with the number of two-pronuclear zygotes. Moreover, the serum levels of AT-TPO ≥ 305,0 IU/ml are reliably associated with a higher frequency of suboptimal response to COS and lower clinical pregnancy rate in IVF (IVF/ICSI) cycles.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: ru
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Vestnik of St Petersburg University. Medicine;Volume 17; Issue 4
metadata.lang: -
metadata.name: dc.subject
metadata.value: antibodies
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: AT-TPO
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: IVF/ICSI
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: suboptimal response
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: embryos
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: clinical pregnancy
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Autoimmune markers in prognosis of Assisted Reproductive Technology efficiency
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 01.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/41627/1/01.pdf
resources.format: Adobe PDF
resources.size: 806,39 kB