title: Hyperproduction of von Willebrand factor as an additional criteria for prolonging antiplatelet therapy after acute coronary syndrome
metadata.name: dc.contributor.author
metadata.value: Alekseeva, Irina V.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Urazgildeeva, Soreya A.
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2023-08-17T15:29:11Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2023-08-17T15:29:11Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2023-03
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Alekseeva I. V., Urazgildeeva S. A. Hyperproduction of von Willebrand factor as an additional criteria for prolonging antiplatelet therapy after acute coronary syndrome. Vestnik of Saint Petersburg University. Medicine, 2023, vol. 18, issue 1, pp. 28–37. https://doi.org/10.21638/spbu11.2023.103 (In Russian)
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/spbu11.2023.103
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/43762
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: The purpose of the study was to assess the prospects for using the von Willebrand factor as an
  additional criterion for prolonging dual antiplatelet therapy in patients at risk of developing
  cardiovascular complications after acute coronary syndrome. The study involved 80 patients who underwent acute coronary syndrome and/or surgical treatment of coronary heart disease.
  In addition to the standard clinical study, the level of von Willebrand factor was determined
  in all patients. In a prospective follow-up after two years, the incidence of recurrent
  cardiovascular complications was assessed and the need for prolongation of dual antiplatelet
  therapy was retrospectively calculated using a risk assessment scale. Among patients with normal
  level of von Willebrand factor, no cardiovascular complications were recorded after two
  years of follow-up. A number of the most important factors were identified, including the
  von Willebrand factor, were used in the predictive model for the development of recurrent
  cardiovascular complications. The classification ability of the model showed 92.5 % agreement
  between the forecast results and the observation results. According to the risk score, longerterm
  dual antiplatelet therapy was required in 24 patients, only 6 of whom developed cardiovascular
  complications. Of the 13 patients with such complications, six patients needed to
  prolong therapy according to the risk assessment scale, and 4 patients required the standard
  duration of therapy. When using the prognostic model developed by us, the percentage of coincidence
  of the predicted unfavorable course of the disease with the actual development of a
  cardiovascular complication was higher: in 8 out of 13 cases. The developed prognostic model,
  including the determination of the von Willebrand factor level, makes it possible to predict
  with high reliability and certainty the likelihood of developing cardiovascular complications
  in patients with early coronary atherosclerosis and can be used to clarify the indications for
  prolonged dual antiplatelet therapy in addition to the risk assessment scale, in patients not
  undergoing percutaneous coronary intervention inclusive.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: ru
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Vestnik of St Petersburg University. Medicine;Volume 18; Issue 1
metadata.lang: -
metadata.name: dc.subject
metadata.value: dual antiplatelet therapy
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: dual antiplatelet therapy score
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: von Willebrand factor
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: cardiovascular events
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Hyperproduction of von Willebrand factor as an additional criteria for prolonging antiplatelet therapy after acute coronary syndrome
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 03.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/43762/1/03.pdf
resources.format: Adobe PDF
resources.size: 616,28 kB