title: Organ-specific transcripts as a source of gene multifunctionality: lessons learned from the Drosophila melanogaster sbr (Dm nxf1) gene
metadata.name: dc.contributor.author
metadata.value: Mamon, Ludmila
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Ginanova, Viktoria
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Kliver, Sergey
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Toropko, Mariya
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Golubkova, Elena
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2019-08-28T22:00:55Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2019-08-28T22:00:55Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2019-06
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Mamon, L., Ginanova, V., Kliver, S., Toropko, M., and Golubkova, E. 2019. Organ-specific transcripts as a source of gene multifunctionality: lessons learned from the Drosophila melanogaster sbr (Dm nxf1) gene. Bio. Comm. 64(2): 146–157.
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/spbu03.2019.206
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/16210
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: Analysis of the transcriptomes of different organisms has demonstrated that a single gene can have multiple transcripts. The sources of transcriptional variability are the alternative promoters, polyadenylation sites, splicing, and RNA editing. A comparison of the organisms of different taxa has demonstrated that the complexity of organization during evolution arises not due to an increase in the number of protein-coding genes. The greatest variability of transcripts is specific to the nervous and germinal systems. A variety of mechanisms providing for the complexity of the transcriptome ensures a precise and coordinated regulation of organ-specific functions through a combination of cis-acting elements and trans-acting factors. The D. melanogaster sbr (Dm nxf1) gene has proven to be an excellent model for investigating mechanisms potentially leading to the emergence of multiple products with various functions.
metadata.lang: en_GB
metadata.name: dc.description.sponsorship
metadata.value: This work was supported by the Russian Foundation for Basic Research (19-04-01255 а).
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Biological Communications;Volume 64; Issue 2
metadata.lang: -
metadata.name: dc.subject
metadata.value: nxf (nuclear export factor)
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: D. melanogaster
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: alternative splicing
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: intron retention
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: transcriptional variability
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: alternative polyadenylation
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Organ-specific transcripts as a source of gene multifunctionality: lessons learned from the Drosophila melanogaster sbr (Dm nxf1) gene
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 146-157.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/16210/1/146-157.pdf
resources.format: Adobe PDF
resources.size: 659,19 kB