title: Role of the MBP protein in myelin formation and degradation in the brain
metadata.name: dc.contributor.author
metadata.value: Shenfeld, Aleksandr
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Galkin, Alexey
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2022-10-11T13:23:20Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2022-10-11T13:23:20Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2022-06
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Shenfeld, A. and Galkin, A. 2022. Role of the MBP protein in myelin formation and degradation in the brain. Bio. Comm. 67(2): 127–138. https://doi.org/10.21638/spbu03.2022.206
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/spbu03.2022.206
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/38272
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: The compact myelin sheath functions as an insulator for efficient conduction of
  nerve impulses. The formation of myelin sheaths around the axons of the most
  actively functioning neurons continues not only at the stage of brain development,
  but also in the process of learning and acquiring certain skills. Pathological
  or age-related disruption in myelin results in nerve conduction failure and
  neurodegeneration. Myelin Basic Protein (MBP) is the main constituent of the
  myelin sheath, representing about 30 % of the total myelin proteins in the central
  nervous system. Deletion in the MBP coding gene in mutant mice causes a
  severe neurological phenotype associated with rapid death of newborns. In this
  review, we discuss the current understanding of the role of the MBP protein in
  the formation of compact myelin and in neurodegeneration associated with
  demyelination.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Biological Сommunications;Volume 67; Issue 2
metadata.lang: -
metadata.name: dc.subject
metadata.value: myelin
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: MBP
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: multiple sclerosis
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: oligodendrocyte
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: axon
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: mammalian brain
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: amyloid
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Role of the MBP protein in myelin formation and degradation in the brain
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 06.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/38272/1/06.pdf
resources.format: Adobe PDF
resources.size: 1,62 MB