title: Sex-dependent effects of chronic intermittent ethanol treatment in Wistar rats
metadata.name: dc.contributor.author
metadata.value: Dorofeikova, Mariia
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Antonova, Irina
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Gromova, Galina
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Veraksa, Anastasia
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Filatova, Elena
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Egorov, Alexei
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2023-12-04T18:13:09Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2023-12-04T18:13:09Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2023-09
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Dorofeikova, M., Antonova, I., Gromova, G., Veraksa, A., Filatova, E., and Egorov, A. 2023. Sex-dependent effects of chronic intermittent ethanol treatment in Wistar rats. Bio. Comm. 68(3): 164–172. https://doi.org/10.21638/spbu03.2023.304
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/spbu03.2023.304
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/44453
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: Multiple behavioral parameters are associated with vulnerability to alcohol dependence,
  but the contribution of such factors as cognitive flexibility and sex
  differences still require further clarification. Our goal was to assess how sex
  differences mediate relationships between cognitive flexibility, affective state,
  hierarchy and ethanol preference before and after chronic intermittent ethanol
  (CIE) exposure in Wistar rats. The results of our study revealed sex-dependent
  changes in ethanol preference and locomotor activity throughout the time.
  Anxiety levels were sex-dependently affected by ethanol exposure with a dramatic
  decrease in ethanol-exposed females. Similarly, striatal tyrosine hydroxylase
  expression was affected by CIE in a sex-dependent manner, with ethanolexposed
  females having higher expression than males. Baseline cognitive flexibility
  was better in rats with higher locomotor activity and lower anxiety levels
  but did not correlate with ethanol preference in rats. Taken together, these
  results are important for understanding sex-dependent alterations in brain and
  behavior induced by alcohol. This provides important insights into understanding
  sex differences in the risk for mental disorders.
metadata.lang: en_GB
metadata.name: dc.description.sponsorship
metadata.value: The work was carried out with the
  support of the State Program, topic No. 075-
  0152-22-00.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Biological Сommunications;Volume 68; Issue 3
metadata.lang: -
metadata.name: dc.subject
metadata.value: chronic intermittent ethanol exposure
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: ethanol preference
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: alcohol
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: sex differences
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: anxiety
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: cognitive flexibility
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: tyrosine hydroxylase
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: striatum
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: rat
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Sex-dependent effects of chronic intermittent ethanol treatment in Wistar rats
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 04.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/44453/1/04.pdf
resources.format: Adobe PDF
resources.size: 909,19 kB