title: Pronounced species divergence in corticospinal tract reorganization and functional recovery after lateralized spinal cord injury favors primates
metadata.name: dc.contributor.author
metadata.value: Friedli, Lucia
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Rosenzweig, Ephron S
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Barraud, Quentin
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Schubert, Martin
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Dominici, Nadia
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Awai, Lea
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Nielson, Jessica L
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Musienko, Pavel
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Nout-Lomas, Yvette
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Zhong, Hui
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Zdunowski, Sharon
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Roy, Roland R
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Strand, Sarah C
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: van den Brand, Rubia
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Havton, Leif A
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Beattie, Michael S
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Bresnahan, Jacqueline C
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Bézard, Erwan
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Bloch, Jocelyne
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Edgerton, V Reggie
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Ferguson, Adam R
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Curt, Armin
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Tuszynski, Mark H
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Courtine, Grégoire
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2016-04-25T18:01:20Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2016-04-25T18:01:20Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2015-08-26
metadata.lang: -
metadata.name: dc.identifier
metadata.value: 10.1126/scitranslmed.aac5811
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Sci Transl Med. 2015 Aug 26;7(302):302ra134. doi: 10.1126/scitranslmed.aac5811
metadata.lang: -
metadata.name: dc.identifier.issn
metadata.value: 1946-6242
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: 10.1126/scitranslmed.aac5811
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/2125
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: Experimental and clinical studies suggest that primate species exhibit greater recovery after lateralized compared to symmetrical spinal cord injuries. Although this observation has major implications for designing clinical trials and translational therapies, advantages in recovery of nonhuman primates over other species have not been shown statistically to date, nor have the associated repair mechanisms been identified. We monitored recovery in more than 400 quadriplegic patients and found that functional gains increased with the laterality of spinal cord damage. Electrophysiological analyses suggested that corticospinal tract reorganization contributes to the greater recovery after lateralized compared with symmetrical injuries. To investigate underlying mechanisms, we modeled lateralized injuries in rats and monkeys using a lateral hemisection, and compared anatomical and functional outcomes with patients who suffered similar lesions. Standardized assessments revealed that monkeys and humans showed greater recovery of locomotion and hand function than did rats. Recovery correlated with the formation of corticospinal detour circuits below the injury, which were extensive in monkeys but nearly absent in rats. Our results uncover pronounced interspecies differences in the nature and extent of spinal cord repair mechanisms, likely resulting from fundamental differences in the anatomical and functional characteristics of the motor systems in primates versus rodents. Although rodents remain essential for advancing regenerative therapies, the unique response of the primate corticospinal tract after injury reemphasizes the importance of primate models for designing clinically relevant treatments.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Pronounced species divergence in corticospinal tract reorganization and functional recovery after lateralized spinal cord injury favors primates
metadata.lang: en_GB
resources.filename: Sci Tr med 2015.docx
resources.url: https://dspace.spbu.ru/bitstream/11701/2125/1/Sci%20Tr%20med%202015.docx
resources.format: Microsoft Word XML
resources.size: 3,43 MB