title: Contribution of cytosine desaminases of AID/APOBEC family to carcinogenesis
metadata.name: dc.contributor.author
metadata.value: Zotova, Irina
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Stepchenkova, Elena
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Pavlov, Youri
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2019-08-28T21:42:12Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2019-08-28T21:42:12Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2019-06
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Zotova, I., Stepchenkova, E., and Pavlov, Y. 2019. Contribution of cytosine desaminases of AID/APOBEC family to carcinogenesis. Bio. Comm. 64(2): 110–123.
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/spbu03.2019.203
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/16207
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: Cytosine deaminases of the AID/APOBEC family have a weighty influence on human health. These enzymes are part of the innate and humoral immunity; they participate in lipid metabolism and muscle development, protect cells from viruses and regulate retrotransposition. If the activity of AID/APOBEC deaminases is misregulated, they can become “weapons of mass destruction,” causing deaminations in unprotected single-stranded DNA regions leading to genome-wide mutagenesis. Ultimately, mutations contribute to cell malignancy and rapid evolution of cancer cells, helping them to evade the organism’s defense. Also, hypermutable tumor cells develop resistance to anti-cancer drugs. Here we overview current understanding of the structure, functions, and regulation of AID/APOBEC cytosine deaminases in connection to carcinogenesis.
metadata.lang: en_GB
metadata.name: dc.description.sponsorship
metadata.value: Buffett Cancer Center Pilot Grant 07-2018 to YP; Assignment of Russian Federation Government № 0112-2019-0001 to ES.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Biological Communications;Volume 64; Issue 2
metadata.lang: -
metadata.name: dc.subject
metadata.value: Cytosine deaminases AID/APOBEC
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: DNA damage
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: mutation
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: cancer
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Contribution of cytosine desaminases of AID/APOBEC family to carcinogenesis
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 110-123.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/16207/1/110-123.pdf
resources.format: Adobe PDF
resources.size: 2,47 MB