title: Gender characteristics of autoimmune hypogonadism
metadata.name: dc.contributor.author
metadata.value: Safarian, Galina Kh.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Niauri, Darico A.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Borodina, Yelena S.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Dzhemlikhanova, Lyailya Kh.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Gzgzyan, Alexandr M.
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2020-11-20T16:56:51Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2020-11-20T16:56:51Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2020-03
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Safarian G.Kh., Niauri D.A., Borodina Ye. S., Dzhemlikhanova L.Kh., Gzgzyan A.M. Gender characteristics of autoimmune hypogonadism. Vestnik of Saint Petersburg University. Medicine, 2020, vol. 15, issue 1, pp. 9–23.
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: http://doi.org/10.21638/spbu11.2020.102
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/20799
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: Autoimmune gonadal lesions represent a highly heterogenous conditions affecting men and
  women of reproductive age and resulting in loss of endocrine function and, eventually, infertility. Well-known and well-documented risk factors exist, and the presence or suspicion of
  autoimmune disorder should be regarded as an important one. For the purpose of the present
  study, ELISA kits according to the proprietary technology for detection of antitesticular and
  antiovarian antibodies were developed. Among men with autoimmune orchitis an increased
  level of antibodies to steroid-producing testicular cells, decreased serum total and free testosterone and altered semen parameters were found. Combined autoimmune diseases were
  present (autoimmune thyroiditis, vitiligo, type 1 diabetes) in 13.5% of cases. In women with
  autoimmune oophoritis the main finding was anovulation with preserved serum FSH and LH
  levels (91.6%) and luteal insufficiency (8.4%). In total, 19.4% of patients had other autoimmune diseases (autoimmune thyroiditis, vitiligo, chronic autoimmune hepatitis, rheumatoid
  arthritis, systemic lupus erythematosus).
metadata.lang: en_GB
metadata.name: dc.description.sponsorship
metadata.value: The work is supported by a grant from the Government of the Russian Federation (contract
  14.W03.31.0009 of 13.02.2017) for state support of scientific research conducted under the supervision of
  leading scientists.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Vestnik of St Petersburg University. Medicine;Volume 15; Issue 1
metadata.lang: -
metadata.name: dc.subject
metadata.value: antiovarian antibodies
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: antitesticular antibodies
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: ovarian insufficiency
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: hypogonadism
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Gender characteristics of autoimmune hypogonadism
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 9-23.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/20799/1/9-23.pdf
resources.format: Adobe PDF
resources.size: 1,56 MB