title: Natural molecules as modulators of epigenetic silencing in human cells for cancer care and aging
metadata.name: dc.contributor.author
metadata.value: Kosianova, Aleksandra
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Tiasto, Vladlena
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Yatsunskaya, Margarita
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Khotimchenko, Yuri
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Kagansky, Alexander
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2021-01-21T21:06:10Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2021-01-21T21:06:10Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2020-12
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Kosianova, A., Tiasto, V., Yatsunskaya, M., Khotimchenko, Yu., and Kagansky, A.† 2020. Natural molecules as modulators of epigenetic silencing in human cells for cancer care and aging. Bio. Comm. 65(4): 315–330.
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/spbu03.2020.405
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/22660
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: The etiology and pathogenesis of malignant tumor growth are associated with
  impaired gene expression, leading to accelerated proliferation, evasion of
  apoptosis, and metabolic deregulations with abnormal blood supply and innervation.
  Currently, hundreds of tumor suppressor genes and proto-oncogenes
  are known. Mutations, epigenetic alterations, exposure to viruses, and other
  environmental factors can cause pathological changes in gene expression. The
  key mechanisms of carcinogenesis are now considered to be linked to epigenetic
  events. A better understanding of epigenetic targets and pathways is needed
  to develop new strategies in antitumor chemotherapy. The majority of modern
  cancer drugs were taken from nature, yet only a small fraction of natural molecular
  diversity has been explored to date. Therefore, there is great interest in
  identifying new natural molecules for modulating gene expression by rewiring
  epigenetic pathways. This review is focused on examples of known natural molecules
  available to biomedicine, especially ones capable of modulating epigenetic
  landscapes and therefore relevant for cancer prevention and aging.
metadata.lang: en_GB
metadata.name: dc.description.sponsorship
metadata.value: This work was supported by
  the Russian Science Foundation (Project
  No. 20-15-00378).
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Biological Сommunications;Volume 65; Issue 4
metadata.lang: -
metadata.name: dc.subject
metadata.value: cancer
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: aging
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: natural products
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: silencing
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: methylation
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: histone modification
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: signaling pathways
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Natural molecules as modulators of epigenetic silencing in human cells for cancer care and aging
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 315-330.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/22660/1/315-330.pdf
resources.format: Adobe PDF
resources.size: 941,75 kB