title: Allelic variants of hereditary prions: The bimodularity principle
metadata.name: dc.contributor.author
metadata.value: Tikhodeyev, Oleg N
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Tarasov, Oleg V
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Bondarev, Stanislav A
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2017-08-03T11:55:47Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2017-08-03T11:55:47Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2017-01-02
metadata.lang: -
metadata.name: dc.identifier
metadata.value: 10.1080/19336896.2017.1283463
metadata.lang: -
metadata.name: dc.identifier.issn
metadata.value: 1933-690X
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/7025
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: Modern biology requires modern genetic concepts equally valid for all discovered mechanisms of inheritance, either "canonical" (mediated by DNA sequences) or epigenetic. Applying basic genetic terms such as "gene" and "allele" to protein hereditary factors is one of the necessary steps toward these concepts. The basic idea that different variants of the same prion protein can be considered as alleles has been previously proposed by Chernoff and Tuite. In this paper, the notion of prion allele is further developed. We propose the idea that any prion allele is a bimodular hereditary system that depends on a certain DNA sequence (DNA determinant) and a certain epigenetic mark (epigenetic determinant). Alteration of any of these 2 determinants may lead to establishment of a new prion allele. The bimodularity principle is valid not only for hereditary prions; it seems to be universal for any epigenetic hereditary factor.
metadata.lang: en_GB
metadata.name: dc.description.sponsorship
metadata.value: The authors acknowledge Saint-Petersburg State University for the research grant 1.37.291.2015 (SB). This work was also supported by RFBR (15-04-06650, 16-34-00582(SB)) and by the grant of the President of the Russian Federation (NS-9513.2016.4).
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: 11;1
metadata.lang: -
metadata.name: dc.source
metadata.value: Prion
metadata.lang: -
metadata.name: dc.subject
metadata.value: amyloid
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: conformational template
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: epigenetic inheritance
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: prion
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: prion strain
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: prion variant
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: the bimodularity principle
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Allelic variants of hereditary prions: The bimodularity principle
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 2017_Tikhodeyev_Tarasov_Bondarev_Prion.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/7025/1/2017_Tikhodeyev_Tarasov_Bondarev_Prion.pdf
resources.format: Adobe PDF
resources.description: Article final draft with figures
resources.size: 1,17 MB