title: Interdisciplinary issue: Multiple aura continua coexisting with the antiphospholipid activity of homeostasis and the possibility of therapy with Levetiracetam and Sulodexide
metadata.name: dc.contributor.author
metadata.value: Elchaninov, Aleksandr P.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Amosova, Nadezhda V.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Zuravlev, Pavel V.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Bogatkova, Elena V.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Morozova, Inna L.
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2019-01-29T10:28:50Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2019-01-29T10:28:50Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2018-12
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Elchaninov A. P., Amosova N. V., Zuravlev P. V., Bogatkova E. V., Morozova I. L. Interdisciplinary issue: Multiple aura continua coexisting with the antiphospholipid activity of homeostasis and the possibility of therapy with Levetiracetam and Sulodexide. Vestnik of Saint Petersburg University. Medicine, 2018, vol. 13, issue 4, pp. 328–343.
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: 10.21638/11701/spbu11.2018.401
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/15349
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: The antiphospholipid activity of hemostasis (APLAH) favours pathological blood clot organisation,
  endothelial dysfunction and bioenergetic hypoxia. The prevalence of epilepsies in
  patients with antiphospholipid syndrome (APS) is 8,6 % for adults. Hypoxia coexisting with
  antiphospholipid syndrome leads to the development of status epilepticus (SE) in 10–12 % of
  cases. The temporal form of focal epilepsy is the most common form, and it is characterised
  by significant polymorphism of clinical manifestations. Also, the variants of masked epilepsy
  (ME) occur in the form of aura continua (AC) — the status or auras without alteration of
  consciousness. 6 women aged between 40 and 68 years with prolonged somatosensorial aura
  had functional hyposplenism and lactic acidosis of blood. 2 of them also had hyperproduction
  of antiphospholipid antibodies. Based on the research results, it was found that Levetiracetam
  (Keppra) is the preferable medication among antiepileptic drugs (AED) in cases of temporal
  epilepsy (TE) resistant to therapy. At the same time, Sulodexide (Vessel Due F) proved to be an effective drug due to dominant microvasculature damage in patients with antiphospholipid
  syndrome. It has an antiplatelet effect, normalises the state of the endothelial tissue, has a
  profibrinolytic and antiatherogenic effect.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: ru
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Vestnik of St Petersburg University. Medicine;Volume 13; Issue 4
metadata.lang: -
metadata.name: dc.subject
metadata.value: aura continua
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: the antiphospholipid activity of hemostasis
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: a zone of contiguous blood supply
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: hypoxia
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: Levetiracetam
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: Sulodexide
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Interdisciplinary issue: Multiple aura continua coexisting with the antiphospholipid activity of homeostasis and the possibility of therapy with Levetiracetam and Sulodexide
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 01-Elchaninov.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/15349/1/01-Elchaninov.pdf
resources.format: Adobe PDF
resources.size: 1,26 MB