title: Hi-C analysis of genomic contacts revealed karyotype abnormalities in chicken HD3 cell line
metadata.name: dc.contributor.author
metadata.value: Maslova, A
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Plotnikov, V
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Nuriddinov, M
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Gridina, M
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Fishman, V
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Krasikova, A
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2023-07-18T11:40:27Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2023-07-18T11:40:27Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2023-02-07
metadata.lang: -
metadata.name: dc.identifier
metadata.value: 10.1186/s12864-023-09158-y
metadata.lang: -
metadata.name: dc.identifier.issn
metadata.value: 10.1186/s12864-023-09158-y
metadata.lang: -
metadata.name: dc.identifier.issn
metadata.value: 10.1186/s12864-023-09158-y
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/41747
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: Karyotype abnormalities are frequent in immortalized continuous cell lines either transformed or derived from primary tumors. Chromosomal rearrangements can cause dramatic changes in gene expression and affect cellular phenotype and behavior during in vitro culture. Structural variations of chromosomes in many continuous mammalian cell lines are well documented, but chromosome aberrations in cell lines from other vertebrate models often remain understudied. The chicken LSCC-HD3 cell line (HD3), generated from erythroid precursors, was used as an avian model for erythroid differentiation and lineage-specific gene expression. However, karyotype abnormalities in the HD3 cell line were not assessed. In the present study, we applied high-throughput chromosome conformation capture to analyze 3D genome organization and to detect chromosome rearrangements in the HD3 cell line.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Hi-C analysis of genomic contacts revealed karyotype abnormalities in chicken HD3 cell line
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: Maslova_et_al-2023-BMC_Genomics.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/41747/1/Maslova_et_al-2023-BMC_Genomics.pdf
resources.format: Adobe PDF
resources.size: 1,8 MB