title: Thioflavin S binds nonamyloid protein structures in lampbrush chromosomes of Gallus gallus domesticus
metadata.name: dc.contributor.author
metadata.value: Siniukova, Vera
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Galkina, Svetlana
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Galkin, Alexey
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2022-10-11T12:07:07Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2022-10-11T12:07:07Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2022-03
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Siniukova, V., Galkina, S., and Galkin, A. 2022. Thioflavin S binds nonamyloid protein structures in lampbrush chromosomes of Gallus gallus domesticus. Bio. Comm. 67(1): 57–62. https://doi. org/10.21638/spbu03.2022.106
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi. org/10.21638/spbu03.2022.106
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/38265
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: Proteins that normally function in amyloid form are found in bacteria, yeast,
  plants and vertebrates, including humans. In particular, amyloid fibrils and
  amyloid-like structures are described in the germ cells of various organisms.
  Recently we showed that in chicken oocytes there are some nuclear structures
  that are stained by the amyloid-specific dye thioflavin S. Here we demonstrate
  that thioflavin S binds giant terminal RNP aggregates in chicken lampbrush
  chromosomes. However, these structures are not stained with Congo red and
  conformation-dependent anti-amyloid antibodies. Thus, thioflavin S stains
  chromosome-associated proteins that do not have amyloid properties. These
  data indicate that thioflavin S must be used with caution when identifying new
  functional and pathological amyloids.
metadata.lang: en_GB
metadata.name: dc.description.sponsorship
metadata.value: The reported study was funded by
  the Russian Foundation for Basic Research
  (project No. 19-34-90082).
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Biological Сommunications;Volume 67; Issue 1
metadata.lang: -
metadata.name: dc.subject
metadata.value: amyloid
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: thioflavin S
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: Congo red
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: anti-amyloid antibodies
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: chicken
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: lampbrush chromosomes
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Thioflavin S binds nonamyloid protein structures in lampbrush chromosomes of Gallus gallus domesticus
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 06.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/38265/1/06.pdf
resources.format: Adobe PDF
resources.size: 1,64 MB