title: Melatonin levels and fetal growth restriction: Clinical insights and analytical approaches
metadata.name: dc.contributor.author
metadata.value: Bolotskikh, Vyacheslav M.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Novitskaya, Ekaterina V.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Polyakova, Victoria О.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Marin, Egor V.
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2024-11-22T17:50:30Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2024-11-22T17:50:30Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2024-06
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Bolotskikh V. M., Novitskaya E. V., Polyakova V. О., Marin E. V. Melatonin levels and fetal growth restriction: Clinical insights and analytical approaches. Vestnik of Saint Petersburg University. Medicine, 2024, vol. 19, issue 2, pp. 128–139. https://doi.org/10.21638/spbu11.2024.203
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/spbu11.2024.203
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/47990
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: Fetal growth restriction is a prevalent complication of pregnancy. Fetal growth restriction
  entails the pathological restriction of fetal growth, leading to heightened perinatal risks. Placental
  histopathology in fetal growth restriction typically involves incomplete invasion and
  transformation of spiral arteries, as well as impaired uteroplacental blood flow. Often, fetal
  growth restriction is comorbid with preeclampsia. Several theories propose the beneficial
  role of melatonin in reducing fetal growth restriction and preeclampsia. Studies suggest that
  melatonin may enhance neoangiogenesis and oxygenation, crucial processes in pregnancy.
  Melatonin’s expression throughout pregnancy in the human placenta underscores its importance
  in placental function and pregnancy outcomes. This research aims to study clinical and
  anamnestic data in women with fetal growth restriction compared to a control group and analyze
  urinary melatonin levels in both groups. The study, conducted between 2018 and 2021,
  included 66 pregnant women (34 with fetal growth restriction, 32 controls). Enzyme immunoassay
  of urine revealed significantly lower melatonin levels in the fetal growth restriction
  group compared to controls. In conclusion, fetal growth restriction remains a significant challenge,
  warranting new therapeutic approaches. Lower urinary melatonin levels in fetal growth
  restriction patients suggest its potential role in disease pathogenesis. Further research into melatonin’s mechanisms and therapeutic applications is essential for preventing or mitigating
  fetal growth restriction’s clinical manifestations.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Vestnik of St Petersburg University. Medicine;Volume 19; Issue 2
metadata.lang: -
metadata.name: dc.subject
metadata.value: pregnancy
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: fetal growth restriction
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: preeclampsia
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: melatonin
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: enzyme immunoassay
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Melatonin levels and fetal growth restriction: Clinical insights and analytical approaches
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 11-2-2024+для+сайта_24-35.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/47990/1/11-2-2024%2b%d0%b4%d0%bb%d1%8f%2b%d1%81%d0%b0%d0%b9%d1%82%d0%b0_24-35.pdf
resources.format: Adobe PDF
resources.size: 1,05 MB