title: Accumulation of milk increases the width of tight junctions in the epithelium of mouse mammary alveoli
metadata.name: dc.contributor.author
metadata.value: Kruglova, Natalia
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Razgovorova, Irina
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Amasheh, Salah
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Markov, Alexander
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2020-10-02T16:24:18Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2020-10-02T16:24:18Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2020-09
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Kruglova, N., Razgovorova, I., Amasheh, S., and Markov, A. 2020. Accumulation of milk increases the width of tight junctions in the epithelium of mouse mammary alveoli. Bio. Comm. 65(3): 277–280
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/ spbu03.2020.307
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/19743
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: The study of the molecular mechanisms of maintaining the integrity of the epithelium during mechanical stress remains a relevant problem in the physiology
  of tissue barriers. A methodical approach has been applied which makes it possible to reproduce mechanical pressure on the apical region of cells in vivo and
  to study the participation and role of tight junctions in maintaining the integrity of the epithelial structure. Mammary gland tissue specimens from lactating
  control mice and animals after a 20-h interruption of suckling were prepared
  and the width of the tight junction of the secretory epithelium was analyzed. At
  the ultrastructural level, it was shown that accumulation of milk caused a significant increase in the width of the tight junction between epithelial cells. In the
  control group, the width of this structure was 2.1 ± 0.1 µm; in the experimental
  group — 4.2 ± 0.1 μm. The marked increase in the width of tight junctions between epithelial cells is in accordance with an observed increase in the level of
  claudin-1 and -3 in the secretory epithelium and can be interpreted as adaptive
  changes aimed at maintaining the structure of the alveoli.
metadata.lang: en_GB
metadata.name: dc.description.sponsorship
metadata.value: This research was sponsored by
  the Grant of Partnership Programm Freie
  Universität Berlin — Saint Petersburg State
  University.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Biological Сommunications;Volume 65; Issue 3
metadata.lang: -
metadata.name: dc.subject
metadata.value: mammary gland
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: alveolus
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: epithelium
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: tissue barrier
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: tight junction
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: claudins
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: electron microscopy
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Accumulation of milk increases the width of tight junctions in the epithelium of mouse mammary alveoli
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 277-280.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/19743/1/277-280.pdf
resources.format: Adobe PDF
resources.size: 975,14 kB