title: Levels of dopamine, 5-hydroxytryptamine and their metabolites in the striatum of rats of various strains receiving a high-calorie diet
metadata.name: dc.contributor.author
metadata.value: Apryatin, Sergey
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Efimova, Evgenia
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Fesenko, Zoya
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Shumakova, Antonina
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Gmoshinski, Ivan
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2022-01-12T12:55:18Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2022-01-12T12:55:18Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2021-12
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Apryatin, S., Efimova, E., Fesenko, Z., Shumakova, A., and Gmoshinski, I. 2021. Levels of dopamine, 5-hydroxytryptamine and their metabolites in the striatum of rats of various strains receiving a high-calorie diet. Bio. Comm. 66(4): 326–332.
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi. org/10.21638/spbu03.2021.405
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/34133
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: The aim of this work was to study the effect of a high fat and carbohydrate diet (HFCD) and quercetin supplementation on the levels of dopamine (DA), serotonin (5-HT) and their metabolites in Wistar, DA transporter knockout (DAT-KO) and obese Zucker fa/fa rats. Animals received a control diet or HFCD for 62 days. Wistar and Zucker fa/fa rats received quercetin. The contents of DA, 5-HT, norepinephrine (NE), dioxyphenyl acetate (DOPAC), homovanillic acid (HVA) and 5-hydroxyindolyl acetate (5-HIIA) in the striatum were determined by high-performance liquid chromatography (HPLC). DAT-KO homozygotes had lowered DA and increased HVA and DOPAC compared to Wistar rats. HFCD did not affect the content of NE and 5-HT. 5-HT was increased in DAT-KO homozygotes compared with Wistar receiving a control diet. 5-HIIA accumulated in larger amounts in DAT-KO compared to Wistar with the exception of those receiving quercetin with a control diet. Quercetin did not affect the levels of DA, 5-HT and their metabolites.
metadata.lang: en_GB
metadata.name: dc.description.sponsorship
metadata.value: The work was supported by a
  grant from the Russian Science Foundation,
  No. 17-16-01043, for the behavioral
  testing of animals and distribution into
  groups, drawing up of experimental diets,
  animal feeding and biological material
  collection from the striatum. Measurement
  of monoamine levels and genotyping
  of animals was supported by project
  ID 51143531 of the St. Petersburg State
  University, St. Petersburg, Russia.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Biological Сommunications;Volume 66; Issue 4
metadata.lang: -
metadata.name: dc.subject
metadata.value: dopamine
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: 5-hydroxytryptamine
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: rats
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: striatum
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: fat and carbohydrate excess
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: quercetin
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Levels of dopamine, 5-hydroxytryptamine and their metabolites in the striatum of rats of various strains receiving a high-calorie diet
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 326-332.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/34133/1/326-332.pdf
resources.format: Adobe PDF
resources.size: 1,78 MB