title: Role of gene polymorphism of the renin-angiotensin system components in development of cardiovascular diseases, excess body weight and obesity in inhabitants of the Adyghea Republic
metadata.name: dc.contributor.author
metadata.value: Muzhenya, Dmitriy V.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Tuguz, Aminat R.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Lysenkov, Sergey P.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Takushinov, Rustem A.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Ozheva, Raziet Sh.
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2019-01-29T10:31:44Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2019-01-29T10:31:44Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2018-12
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Muzhenya D. V., Tuguz A. R., Lysenkov S. P., Thakushinov R. A., Ozheva R. S. Role of gene polymorphism of the renin-angiotensin system components in development of cardiovascular diseases, excess body weight and obesity in inhabitants of the Adygea Republic. Vestnik of Saint Petersburg University. Medicine, 2018, vol. 13, issue 4, pp. 344–354.
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: 10.21638/11701/spbu11.2018.402
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/15350
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: The aim of the study was to study the polymorphisms of the AGT (Met235Thr; rs699), ACE
  (Ins/Del; rs4646994) and AGTR1 (A1166C; rs5186) genes associated with both CVD risk and
  obesity in the Republic of Adygea. Materials and methods. Polymorphisms (rs699, rs4646994,
  rs5186) are investigated by the single nucleotide polymorphism method (SNP) using allelespecific
  primers in the SNP-express test systems of NPF Liteh with electrophoretic detection
  of results. Distribution of frequencies and associations of AGT, ACE, AGTR1 gene mutations
  has been analyzed in control group (donors, n = 143) of young men and girls at the age
  of 22.32 ± 5.4 years without hereditary burden and clinical manifestations of cardiovascular
  disease, as well as at patients (n=46; 54.26 ± 12.2 years) of the Cardiological Department of
  the Adyghe Republican Clinical Hospital. Experimental data have been analysed by statistical
  methods using the SPSS Statistics 17.0 program. Results. A group of patients with the
  verified diagnoses of heart continuum diseases (DWC), show a statistically significantly increased
  frequency of mutant 1166C locus (p = 0.00003; OR = 3.77 (2.22–6.38)) and pathological
  homozygous C1166C genotype (р = 0.00002; OR = 10.36 (4.69–26.22)) of AGTR1 gene.
  No reliable distinctions have been revealed in a distribution of Met235Thr (AGT), and Ins/
  Del (ACE) alleles in the examined groups of donors and patients at inhabitants of Adyghea
  Republic, as well as no correlation relationships have been identified between frequencies of
  Met235Thr, Ins/Del, and A1166C polymorphisms and obesity. Minor 1166C polymorphism
  of the AGTR1 gene is associated with heart continuum diseases and can be used as an informative
  predictor of cardiovascular diseases for the formation of risk groups, especially
  among persons of young age. The absence of associations between Met235Thr, Ins/Del and
  A1166C allelic variants of genes and dyslipidemia points to need of the analysis of some other
  AGT, ACE and AGTR1 gene polymorphisms obtained as a result of research in the Adyghea
  Republic.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: ru
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Vestnik of St Petersburg University. Medicine;Volume 13; Issue 4
metadata.lang: -
metadata.name: dc.subject
metadata.value: obesity
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: cardiovascular diseases
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: gene polymorphisms
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: renin-angiotensin system
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: molecular genetic markers
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Role of gene polymorphism of the renin-angiotensin system components in development of cardiovascular diseases, excess body weight and obesity in inhabitants of the Adyghea Republic
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 02-Muzhenya.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/15350/1/02-Muzhenya.pdf
resources.format: Adobe PDF
resources.size: 643,36 kB