title: Determination of the most informative indicators of right-ventricular dysfunction in patients with chronic obstructive pulmonary disease
metadata.name: dc.contributor.author
metadata.value: Kharitonov, Mikhail A.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Tarasov, Victor A.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Grishaev, Sergei L.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Filippov, Alexander E.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Cherkashin, Dmitriy V.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Lokshina, Tatyana R.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Varavin, Nikita A.
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2021-02-04T10:56:18Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2021-02-04T10:56:18Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2020-06
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Kharitonov M. A., Tarasov V. A., Grishaev S. L., Filippov A. E., Cherkashin D. V., Lokshina T. R., Varavin N. A. Determination of the most informative indicators of right-ventricular dysfunction in patients with chronic obstructive pulmonary disease. Vestnik of Saint Petersburg University. Medicine, 2020, vol. 15, issue 2, pp. 115–123.
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/spbu11.2020.203
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/23401
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: The aim of the article was the evaluation of structural and functional indicators that reflect
  the nature of right heart remodeling in patients with chronic obstructive pulmonary disease
  (COPD) in order to identify the most informative indicators of right ventricular heart dysfunction.
  The study included 60 patients, who were on inpatient treatment. Patients were divided
  into two groups: I — study group with COPD (n = 30), and II — control group — patients
  of comparable age without COPD (n = 30). During hospitalization, all patients underwent
  ECHO-KG with an emphasis on evaluating the systolic-diastolic parameters of the right
  ventricle. Criteria for inclusion in the study: age over 50 years, presence of COPD, signed informed
  consent when reading the terms of the study. Exclusion criteria: history/course of neoplastic
  or hematological disease, systemic connective tissue diseases, documented ischemic
  disease, valvular heart disease, interstitial lung disease, bronchial asthma. When comparing
  echocardiographic indicators of right ventricular (RV) function detected significant decrease
  of systolic function the RV — TAPSE (16.64 ± 4.0 vs 23.21 ± 2.31; p = 0.043), S’(12.57 ± 1.87 vs.
  14.96 ± 1.09; p = 0.026), estimated RV EF (49.27 ± 9.23 vs 66.12 ± 7.42; p = 0.021), EFSRV
  (55.58 ± 7.16 vs 72.4 ± 13.06; p = 0.01) and higher rates SDLA (49.55 ± 6.0 vs 27.1 ± 5.29;
  p = 0.023) in the study group 1. Measure of right ventricular arterial pairing TAPSE/SDLA was
  significantly reduced compared with the control group (0.36 ± 0.05 vs 0.86 ± 0.14; p = 0.01). In
  the main 1 group of patients with COPD, there was a tendency increase of the myocardial performance
  index (TEI index) (0.76 ± 0.42 vs 0.59 ± 0.22; p = 0.43), which is probably associated with a violation of the relaxation of the right ventricle. To confirm the presence of diastolic
  RV dysfunction in patients with COPD (in comparison with the control group) revealed significant
  changes in the indicators obtained from transtricuspid flow — E/Atk (0.67 ± 0.02 vs
  1.5 ± 0.38; p = 0.016). The dynamics of the degree of severity of right ventricular dysfunction,
  estimated using the proposed indicators, may be another additional characteristic of the success
  of therapy to achieve disease control in patients with COPD.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Vestnik of St Petersburg University. Medicine;Volume 15; Issue 2
metadata.lang: -
metadata.name: dc.subject
metadata.value: right ventricle of the heart
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: echocardiography
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: systolic-diastolic indicators
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: chronic obstructive pulmonary disease
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Determination of the most informative indicators of right-ventricular dysfunction in patients with chronic obstructive pulmonary disease
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 115-123.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/23401/1/115-123.pdf
resources.format: Adobe PDF
resources.size: 593,99 kB