title: Purinergic regulation: From a risky hypothesis to a triumphant theory
metadata.name: dc.contributor.author
metadata.value: Kamran Sarkandi, Mohammad
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Serebryanaya, Natalia B.
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2022-03-09T20:14:55Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2022-03-09T20:14:55Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2021-09
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Kamran Sarkandi M., Serebryanaya N. B. Purinergic regulation: From a risky hypothesis to a triumphant theory. Vestnik of Saint Petersburg University. Medicine, 2021, vol. 16, issue 3, pp. 190– 202.
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/spbu11.2021.306
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/35583
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: With the discovery of the ATP structure in 1929, significant progress was made in understanding
  the role of nucleosides and nucleotides in the body. One of the most important breakthroughs
  is associated with the determination of the function of an autacoid in ATP, a participant
  in purinergic signal transmission. For the first time, this function of ATP was pointed
  out by Professor Geoffrey Burnstock in 1972. Purinergic signaling activators are extracellular
  nucleotides including ATP, ADP, UTP, UDP, and adenosine nucleoside. The purinergic signaling
  pathway begins with the synthesis and intracellular accumulation of nucleotides, and
  then their release from the cell under various physiological and pathological conditions. In
  the extracellular spaces, nucleotides are hydrolyzed by various enzymes with the removal of
  phosphate groups, which leads to the appearance of various regulatory molecules that interact
  with P1 and P2 purinergic receptors. This ligand-receptor interaction changes the functional
  state of the target cell. In turn, the expression of purinergic receptors changes depending on
  the functional state of the cell. The participation of purinergic regulation in the development
  of many diseases indicates that by changing the concentration of signaling molecules, it is possible
  to change the course of pathological processes, in particular the activity of inflammation
  and the direction of immune responses. This article provides a brief review of the literature on
  the structure of nucleotide and nucleoside autacoids, enzymes involved in their metabolism,
  specific purinergic receptors.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Vestnik of St Petersburg University. Medicine;Volume 16; Issue 3
metadata.lang: -
metadata.name: dc.subject
metadata.value: purinergic signaling pathway
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: Adenosine
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: ATP
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: Purinergic regulation
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: P1 and P2 receptors
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Purinergic regulation: From a risky hypothesis to a triumphant theory
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 190-202.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/35583/1/190-202.pdf
resources.format: Adobe PDF
resources.size: 1,18 MB