title: Ethanolic extract of Aloe arborescens stimulates neonatal rat calvarial cells proliferation, migration and osteogenic differentiation
metadata.name: dc.contributor.author
metadata.value: Blanco, Nicolás Olegario
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Gili, Valeria
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Laiuppa, Juan Andrés
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Graciela, Edith Santillán
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2023-12-04T18:07:39Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2023-12-04T18:07:39Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2023-09
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Blanco, N. O., Gili, V., Laiuppa, J. A., and Santillán, G. E. 2023. Ethanolic extract of Aloe arborescens stimulates neonatal rat calvarial cells proliferation, migration and osteogenic differentiation. Bio. Comm. 68(3): 151–163. https://doi.org/10.21638/ spbu03.2023.303
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/ spbu03.2023.303
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/44452
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: The medicinal plant Aloe arborescens Miller has chemical compounds that could
  stimulate the activity of bone-forming cells, but no studies have been found in
  this regard. We evaluated the effects of different dilutions of aqueous (1/10;
  1/100; 1/1000) or ethanolic (1/1000; 1/2000; 1/5000) extracts of parenchyma
  from A. arborescens on the viability, proliferation, migration and osteogenic differentiation
  of primary cell cultures from neonatal rat calvaria. In none of the
  conditions studied did cell viability decrease (p ≤ 0.01). Furthermore, the 1/5000
  ethanolic extract dilution showed a positive effect on cell viability at 48 h and 72 h
  and the latter was correlated with a 27 % (p ≤ 0.01) increase in cell proliferation.
  Ethanolic extract significantly stimulated cell migration and cultured mineralization
  with respect to control, showing the maximal effect at a dilution 1/5000. Together,
  the results show that the A. arborescens extracts do not have toxic effects.
  In addition, ethanolic extract stimulates proliferation, migration and osteogenic
  differentiation of rat calvarial cells, suggesting a potential bone anabolic action.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Biological Сommunications;Volume 68; Issue 3
metadata.lang: -
metadata.name: dc.subject
metadata.value: osteoblast
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: proliferation
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: migration
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: osteogenic differentiation
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Ethanolic extract of Aloe arborescens stimulates neonatal rat calvarial cells proliferation, migration and osteogenic differentiation
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 03.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/44452/1/03.pdf
resources.format: Adobe PDF
resources.size: 18,99 MB