title: Optogenetics: Applications in neurobiology
metadata.name: dc.contributor.author
metadata.value: Mikhailova, Maria
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Deal, Alex
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Budygin, Evgeny
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Gainetdinov, Raul
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2018-06-06T09:26:38Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2018-06-06T09:26:38Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2017-12
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Mikhailova, M., Deal, A., Budygin, E., and Gainetdinov, R. 2017. Optogenetics: Applications in neurobiology. Bio. Comm. 62(4): 261–271.
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: 10.21638/11701/spbu03.2017.405
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/10260
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: Commonly used neuromodulation techniques such as electrical stimulation or
  pharmacologic intervention have some technical limitations that preclude dissecting
  particular cell- or pathway-specific functions in the brain, which is composed
  of billions of neurons. An advancement of molecular genetics techniques
  has provided a novel method in neuroscience called optogenetics. Optogenetics
  uses a combination of genetic and optical methods that provide a means
  to, with great temporal precision, experimentally control the activation or suppression
  of specific neuronal sub-populations in heterogeneous brain regions
  where multiple neuronal subtypes exist; this approach can be performed even
  on freely moving animals. Thus, this tool can uniquely assist in establishing causality
  between the disorder and the underlying pathology. Ongoing exploration
  of pathological mechanisms in various animal models of neuropsychiatric
  disorders with precise tools such as optogenetics can provide significant advances
  in the development of more focused approaches to treatment of these
  disorders. Here, we selectively highlight the major advancements gained by the
  use of optogenetic tools to uncover at circuit levels mechanisms relevant to
  neuropsychiatric disorders.
metadata.lang: en_GB
metadata.name: dc.description.sponsorship
metadata.value: This work was supported by
  the Russian Science Foundation (Grant
  no. 14‑50-00069).
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Biological Communications;Volume 62; Issue 4
metadata.lang: -
metadata.name: dc.subject
metadata.value: optogenetics
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: opsin
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: neuropsychiatric disorders
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: addiction
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: schizophrenia
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: stress
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: depression
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: Parkinson’s disease
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: Alzheimer’s disease
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Optogenetics: Applications in neurobiology
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 05-Mikhailova.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/10260/1/05-Mikhailova.pdf
resources.format: Adobe PDF
resources.size: 696,76 kB