title: Constant darkness conditions modulate the effects of melatonin and luzindole on the antioxidant enzyme activities and levels of retinol and α-tocopherol in rats
metadata.name: dc.contributor.author
metadata.value: Kalinina, Svetlana
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Ilyukha, Viktor
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Khizhkin, Evgeniy
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Baishnikova, Irina
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Antonova, Ekaterina
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Morozov, Artem
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2019-11-22T20:51:38Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2019-11-22T20:51:38Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2019-09
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Kalinina, S., Ilyukha, V., Khizhkin, E., Baishnikova, I., Antonova, E., and Morozov, A. 2019. Constant darkness conditions modulate the effects of melatonin and luzindole on the antioxidant enzyme activities and levels of retinol and α-tocopherol in rats. Bio. Comm. 64(3): 211–218.
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/ spbu03.2019.305
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/16626
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: This study was conducted to evaluate the effects of both exogenous melatonin
  and melatonin receptor antagonist luzindole on the activities of antioxidant enzymes
  (AOE) (superoxide dismutase, SOD; catalase, CAT) and the level of lowmolecular
  antioxidant vitamins (retinol, α-tocopherol) in male Wistar rats kept
  in normal light conditions (LD 12:12) or constant darkness (DD). In LD, while
  melatonin had no influence on the studied antioxidants, luzindole caused an increase
  in retinol and a decrease in α-tocopherol contents in the liver compared
  to the control. In DD, with no influence on AOE activities, both drugs exerted
  similar effects on the liver retinol and kidney α-tocopherol contents, increasing
  them in comparison with control. Exposing the animals to DD induced an increase
  in kidney SOD activity and in liver retinol content. Moreover, DD-mel rats
  had higher SOD activity in the liver and kidney and a higher retinol level in the
  liver compared to LD-mel ones; DD-luz rats had a higher liver retinol content
  compared to LD-luz ones. Liver retinol level seems to be the most sensitive to
  influence of DD, melatonin and luzindole; the data are probably connected with
  the involvement of vitamin A in the regulation of circadian rhythms.
metadata.lang: en_GB
metadata.name: dc.description.sponsorship
metadata.value: The study was carried out under
  the state order (project № 0218-2019-0073).
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Biological Communications;Volume 64; Issue 3
metadata.lang: -
metadata.name: dc.subject
metadata.value: constant darkness
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: melatonin
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: luzindole
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: antioxidant enzymes
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: retinol
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: α-tocopherol
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Constant darkness conditions modulate the effects of melatonin and luzindole on the antioxidant enzyme activities and levels of retinol and α-tocopherol in rats
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 211-218.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/16626/1/211-218.pdf
resources.format: Adobe PDF
resources.size: 849,88 kB