title: New perspectives on treatment of gastrointestinal diseases: therapeutic potential of mesenchymal stromal cells
metadata.name: dc.contributor.author
metadata.value: Payushina, Olga
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Tsomartova, Dibakhan
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Chereshneva, Yelizaveta
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Ivanova, Marina
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Pashina, Nataliya
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Tsomartova, Elina
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Kuznetsov, Sergey
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2022-10-25T17:48:11Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2022-10-25T17:48:11Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2022-09
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Payushina, O., Tsomartova, D., Chereshneva, Y., Ivanova, M., Pashina, N., Tsomartova, E., and Kuznetsov, S. 2022. New perspectives on treatment of gastrointestinal diseases: therapeutic potential of mesenchymal stromal cells. Bio. Comm. 67(3): 217–230. https://doi.org/10.21638/spbu03.2022.307
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/spbu03.2022.307
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/38352
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: Mesenchymal stromal cells (MSCs) are a promising resource for cell therapy of
  different organs and systems, including the gastrointestinal tract (GIT). Therapeutic
  effect of MSC transplantation in GIT diseases may be partly due to their
  differentiation into various cellular components of the digestive tube. However,
  more significant is regulatory influence of MSCs on survival, proliferation, and
  differentiation of the gastric and intestinal epithelial cells, as well as their immunomodulatory,
  pro-angiogenic and antifibrotic effects. Data from experiments
  on animals and clinical trials indicate prospect of using MSCs in various
  diseases affecting any parts of GIT. However, effective and safe clinical use of
  MSCs requires an in-depth study of the mechanisms of their therapeutic effect,
  the development of optimal methods of administration, and risk assessment
  of adverse effects. This review analyzes MSC participation in regeneration of
  GIT and systematizes data on the potential of using MSCs in the treatment of
  gastroenterological diseases.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Biological Сommunications;Volume 67; Issue 3
metadata.lang: -
metadata.name: dc.subject
metadata.value: mesenchymal stromal cells
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: gastrointestinal tract
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: esophagus
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: stomach
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: intestines
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: regenerative medicine
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: cell therapy
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: New perspectives on treatment of gastrointestinal diseases: therapeutic potential of mesenchymal stromal cells
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 07.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/38352/1/07.pdf
resources.format: Adobe PDF
resources.size: 1,13 MB