title: Genome response of hippocampal cells to stress in male rats with different excitability of the nervous system
metadata.name: dc.contributor.author
metadata.value: Shcherbinina, Veronika
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Vaido, Alexander
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Khlebaeva, Diana
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Dyuzhikova, Natalia
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Daev, Eugene
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2022-10-11T11:50:03Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2022-10-11T11:50:03Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2022-03
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Shcherbinina, V., Vaido, A., Khlebaeva, D., Dyuzhikova, N., and Daev, E. 2022. Genome response of hippocampal cells to stress in male rats with different excitability of the nervous system. Bio. Comm. 67(1): 12–18. https://doi. org/10.21638/spbu03.2022.102
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/spbu03.2022.102
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/38261
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: Changes of genome stability in hippocampal cells of male rats with hereditary
  high and low thresholds of nervus tibialis response to electric stimuli (HT and LT
  strains, respectively) were studied in unstressed and stressed animals. HT and
  LT originated from Wistar strain, males of which were also used as a control.
  The comet assay was used after prolonged emotional painful stressor action.
  There were no interstrain differences in the spontaneous percentage of DNA
  in comet tails (tDNA). However, the prolonged emotional pain stressor induced
  genome instability differently in animals of different strains. The highest level of
  DNA damage in hippocampal cells was shown in highly sensitive animals of LT
  strain. Males of Wistar strain had intermediate levels of tDNA, while HT animals
  had the lowest stress reactivity.
metadata.lang: en_GB
metadata.name: dc.description.sponsorship
metadata.value: This study was supported by
  the State Program 47 GP “Scientific and
  Technological Development of the Russian
  Federation” (2019–2030), theme No. 0134-
  2019-0002.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Biological Сommunications;Volume 67; Issue 1
metadata.lang: -
metadata.name: dc.subject
metadata.value: DNA damage
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: comet assay
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: stress
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: hippocampus
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: nervous sensitivity
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: selection
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: rats
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: genome instability
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Genome response of hippocampal cells to stress in male rats with different excitability of the nervous system
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 02.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/38261/1/02.pdf
resources.format: Adobe PDF
resources.size: 1,1 MB