title: Haploid yeast cells undergo a reversible phenotypic switch associated with chromosome II copy number
metadata.name: dc.contributor.author
metadata.value: Drozdova, Polina
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Mironova, Ludmila
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Zhouravleva, Galina
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2017-04-22T10:06:02Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2017-04-22T10:06:02Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2016-12-22
metadata.lang: -
metadata.name: dc.identifier
metadata.value: 10.1186/s12863-016-0464-4
metadata.lang: -
metadata.name: dc.identifier.issn
metadata.value: 1471-2156
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/6207
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: SUP35 and SUP45 are essential genes encoding polypeptide chain release factors. However, mutants for these genes may be viable but display pleiotropic phenotypes which include, but are not limited to, nonsense suppressor phenotype due to translation termination defect. [PSI (+)] prion formation is another Sup35p-associated mechanism leading to nonsense suppression through decreased availability of functional Sup35p. [PSI (+)] differs from genuine sup35 mutations by the possibility of its elimination and subsequent re-induction. Some suppressor sup35 mutants had also been shown to undergo a reversible phenotypic switch in the opposite direction. This reversible switching had been attributed to a prion termed [ISP (+)]. However, even though many phenotypic and molecular level features of [ISP (+)] were revealed, the mechanism behind this phenomenon has not been clearly explained and might be more complex than suggested initially.
metadata.lang: en_GB
metadata.name: dc.description.sponsorship
metadata.value: The authors acknowledge the Saint-Petersburg State University for grants
  15.61.2218.2013, 1.37.291.2015 and 1.42.1394.2015 and the Presidential Grant
  Council for the grant NSh-9513.2016.4 for funding this work. The publication
  cost is covered by the authors.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: yeast
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: translation
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Haploid yeast cells undergo a reversible phenotypic switch associated with chromosome II copy number
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 2016 Haploid yeast cells undergo a reversible phenotypic switch associated with chromosome II copy number Drozdova BMC.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/6207/1/2016%20Haploid%20yeast%20cells%20undergo%20a%20reversible%20phenotypic%20switch%20associated%20with%20chromosome%20II%20copy%20number%20Drozdova%20BMC.pdf
resources.format: Adobe PDF
resources.size: 1,42 MB