title: Chapter 7. Mechanisms of antinoceptive response of a sensory neuron
metadata.name: dc.contributor.author
metadata.value: Dik, Olga E.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Nozdrachev, Alexander D.
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2020-12-02T09:30:04Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2020-12-02T09:30:04Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2019
metadata.lang: -
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/11701/9785288059322.08
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/21153
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: The seventh chapter is devoted to the determination of the mechanisms of changes in the dynamic
  complexity of the patterns of impulse activity of nociceptors. As a result of the study of the mechanisms of changes in the dynamic complexity of the patterns of impulse activity of nociceptive
  neurons when the antinociceptive response occurs, it was found that the change in this complexity
  is based on rearrangements in the temporal organization of patterns due to bifurcations of stationary states and limit cycles, leading to the appearance of two types of burst activity. The mechanism
  of correction of the damaging pain effect is based on the molecular mechanism of suppression
  of this activity associated with the modification of the activation gating structure of slow sodium
  NaV1.8 channels under the action of comenic acid, a drug substance of the non-opioid analgesic
  “Anoceptin”. The methodology for analyzing the considered molecular mechanism can be used
  in the search for new pharmacological targets for further research related to the development of
  innovative pharmacological strategies in the correction of pathological conditions.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: ru
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: nonlinear dynamics
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: bifurcations
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: nociceptors
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: bursting
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: slow sodium NaV1.8 channels
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Chapter 7. Mechanisms of antinoceptive response of a sensory neuron
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Book chapter
metadata.lang: en_GB
resources.filename: 132-175.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/21153/1/132-175.pdf
resources.format: Adobe PDF
resources.size: 2,66 MB