title: Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury
metadata.name: dc.contributor.author
metadata.value: Wenger, Nikolaus
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Moraud, Eduardo Martin
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Gandar, Jerome
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Musienko, Pavel
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Capogrosso, Marco
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Baud, Laetitia
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Le Goff, Camille G
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Barraud, Quentin
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Pavlova, Natalia
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Dominici, Nadia
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Minev, Ivan R
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Asboth, Leonie
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Hirsch, Arthur
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Duis, Simone
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Kreider, Julie
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Mortera, Andrea
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Haverbeck, Oliver
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Kraus, Silvio
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Schmitz, Felix
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: DiGiovanna, Jack
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: van den Brand, Rubia
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Bloch, Jocelyne
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Detemple, Peter
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Lacour, Stéphanie P
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Bézard, Erwan
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Micera, Silvestro
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Courtine, Grégoire
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2016-04-25T14:48:25Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2016-04-25T14:48:25Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2016-02
metadata.lang: -
metadata.name: dc.identifier
metadata.value: 10.1038/nm.4025
metadata.lang: -
metadata.name: dc.identifier
metadata.value: 10.1038/nm.4025
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Nat Med. 2016 Feb;22(2):138-45. doi: 10.1038/nm.4025
metadata.lang: en_GB
metadata.name: dc.identifier.issn
metadata.value: 1078-8956
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/2124
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: Electrical neuromodulation of lumbar segments improves motor control after spinal cord injury in animal models and humans. However, the physiological principles underlying the effect of this intervention remain poorly understood, which has limited the therapeutic approach to continuous stimulation applied to restricted spinal cord locations. Here we developed stimulation protocols that reproduce the natural dynamics of motoneuron activation during locomotion. For this, we computed the spatiotemporal activation pattern of muscle synergies during locomotion in healthy rats. Computer simulations identified optimal electrode locations to target each synergy through the recruitment of proprioceptive feedback circuits. This framework steered the design of spatially selective spinal implants and real-time control software that modulate extensor and flexor synergies with precise temporal resolution. Spatiotemporal neuromodulation therapies improved gait quality, weight-bearing capacity, endurance and skilled locomotion in several rodent models of spinal cord injury. These new concepts are directly translatable to strategies to improve motor control in humans.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: Nature publishing group
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: Array paper_accepted_text and figg.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/2124/1/Array%20paper_accepted_text%20and%20figg.pdf
resources.format: Adobe PDF
resources.size: 6,54 MB