title: Growth hormone treatment strategies in assisted reproduction for the poor responder patients
metadata.name: dc.contributor.author
metadata.value: Ob’edkova, Ksenia V.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Gzgzyan, Alexandr M.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Niauri, Dariko A.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Dzhemlikhanova, Liailia Kh.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Kogan, Igor Yu.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Krikheli, Inna O.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Mekina, Irina D.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Lesik, Elena A.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Komarova, Evgenia M.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Mazilina, Maria A.
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2019-11-26T13:17:29Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2019-11-26T13:17:29Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2019-06
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Ob’edkova K. V., Gzgzyan A. M., Niauri D. A., Dzhemlikhanova L. Kh., Kogan I. Yu., Krikheli I. O., Mekina I. D., Lesik E. A., Komarova E. M., Mazilina M. A. Growth hormone treatment strategies in assisted reproduction for the poor responder patients. Vestnik of Saint Petersburg University. Medicine, 2019, vol. 14, issue 2, pp. 132–140.
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/spbu11.2019.205
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/16651
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: The goal of the study was to estimate the efficacy of growth hormone (GH) co-treatment to the
  antagonist protocol in IVF/ ICSI cycles in poor responders. A prospective observational study
  involved 75 patients. All patients underwent standard antagonist protocol with or without GH
  co-treatment. GH additional was given a daily subcutaneous injection of 1.33 mg (equivalent
  to 4 IU) of GH from day 1 of ovarian stimulation until the day of human chorionic gonadotropin
  (hCG). Concentrations of GH, insulin-like growth factor I (IGF-I) and IGF binding
  protein-3 (IGFBP-3) in serum and follicular fluid were analyzed. The GH co-treatment significantly
  lowered effective dose of gonadotropins, duration of stimulation, IGFBP-3 level in
  serum and follicular fluid day of oocytes retrieval. The number of oocytes recovered, metaphase
  II stage (MII) oocytes, 2 pronucleus (2 pn) zygote, good-quality transferred embryos
  were significantly higher in the GH+ group. Only patients GH+ group became pregnant. Positive
  correlation was found between IGF-I level in follicular fluid, dynamics of IGFBP-3 level
  changes during stimulation protocol and number of good-quality transferred embryos in the
  GH+ group. GH administration in IVF/ICSI cycles for poor responders raises ovarian sensitivity
  to the gonadotropin exogenous influence, this way, increasing number of high-quality
  embryos and the probability of pregnancy.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Vestnik of St Petersburg University. Medicine;Volume 14; Issue 2
metadata.lang: -
metadata.name: dc.subject
metadata.value: growth hormone
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: poor ovarian response
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: in vitro fertilization (IVF)
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: assisted reproductive technologies (ART)
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Growth hormone treatment strategies in assisted reproduction for the poor responder patients
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 132-140.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/16651/1/132-140.pdf
resources.format: Adobe PDF
resources.size: 934,99 kB