title: Anti-neuraminidase antibodies against pandemic A/H1N1 influenza viruses in healthy and influenza-infected individuals
metadata.name: dc.contributor.author
metadata.value: Desheva, Yulia
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Sychev, Ivan
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Smolonogina, Tatiana
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Rekstin, Andrey
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Ilyushina, Natalia
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Lugovtsev, Vladimir
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Samsonova, Anastasia
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Go, Aleksey
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Lerner, Anna
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2018-06-19T19:54:47Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2018-06-19T19:54:47Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2018-05-09
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: 2,86
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: eISSN 1932-6203
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/10277
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: The main objective of the study was to evaluate neuraminidase inhibiting (NI) antibodies
  against A/H1N1pdm09 influenza viruses in the community as a whole and after infection.
  We evaluated NI serum antibodies against A/California/07/09(H1N1)pdm and A/South
  Africa/3626/2013(H1N1)pdm in 134 blood donors of different ages using enzyme-linked lectin
  assay and in 15 paired sera from convalescents with laboratory confirmed influenza. The
  neuraminidase (NA) proteins of both A/H1N1pdm09 viruses had minimal genetic divergence,
  but demonstrated different enzymatic and antigenic properties. 5.2% of individuals
  had NI antibody titers  1:20 against A/South Africa/3626/2013(H1N1)pdm compared to
  53% of those who were positive to A/California/07/2009(H1N1)pdm NA. 2% of individuals
  had detectable NI titers against A/South Africa/3626/13(H1N1)pdm and 47.3% were positive
  to A/California/07/2009(H1N1)pdm NA among participants negative to hemagglutinin
  (HA) of A/H1N1pdm09 but positive to seasonal A/H1N1. The lowest NI antibody levels to
  both A/H1N1pdm09 viruses were detected in individuals born between 1956 and 1968. Our
  data suggest that NI antibodies against A/South Africa/3626/13 (H1N1)pdm found in the
  blood donors could have resulted from direct infection with a new antigenic A/H1N1pdm09
  variant rather than from cross-reaction as a result of contact with previously circulating seasonal
  A/H1N1 variants. The immune responses against HA and NA were formed simultaneously
  right after natural infection with A/H1N1pdm09. NI antibodies correlated with virusneutralizing
  antibodies when acquired shortly after influenza infection. A group of middleaged
  patients with the lowest level of anti-NA antibodies against A/California/07/2009
  (H1N1)pdm was identified, indicating the highest-priority vaccination against A/H1N1pdm09
  viruses.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: Public Library of Science
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Anti-neuraminidase antibodies against pandemic A/H1N1 influenza viruses in healthy and influenza-infected individuals
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: journal.pone.0196771.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/10277/1/journal.pone.0196771.pdf
resources.format: Adobe PDF
resources.size: 2,64 MB