title: Cancer as a potential sequela of COVID-19 — should we modify 3D cell culture models accordingly?
metadata.name: dc.contributor.author
metadata.value: Petersen, Elena
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Chudakova, Daria
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Erdyneeva, Daiana
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Zorigt, Dulamsuren
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Shabalina, Evgeniya
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Karalkin, Pavel
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Reshetov, Igor
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2023-12-04T19:20:36Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2023-12-04T19:20:36Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2023-09
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Petersen, E., Chudakova, D., Erdyneeva, D., Zorigt, D., Shabalina, E., Karalkin, P., and Reshetov, I. 2023. Cancer as a potential sequela of COVID-19 — should we modify 3D cell culture models accordingly? Bio. Comm. 68(3): 190–198. https://doi.org/10.21638/spbu03.2023.307
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/spbu03.2023.307
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/44456
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: COVID-19 pandemic was caused by SARS-CoV-2, a novel virus from the family
  Coronaviridae, firstly identified in Wuhan, China in 2019. COVID-19 remains
  one of the main challenges of healthcare, given growing numbers of people
  with COVID-19 in anamnesis, and given the long-lasting consequences and
  complications of this disease. Cancer is one of the most common diseases in
  the world, thus a big part of the population is affected by both COVID-19 and
  cancer. In this succinct review we refer to several recent works expressing a
  view that COVID-19 might be oncogenic, and describe molecular mechanisms
  of such phenomena. Next, we describe several tumorigenic changes in the tissue
  microenvironment as COVID-19 sequelae, which can potentially affect cancer
  pathogenesis and response of a tumor to therapy. 3D cell culture models
  are a “golden standard” of in vitro studies in translational oncology. To the best
  of our knowledge, 3D cell culture systems to study tumor behavior in the tissue
  microenvironment affected by COVID-19 have not been developed yet. We
  propose several actionable steps which can be taken to modify existing 3D cell
  culture models accordingly, to address the needs of translational oncology in
  the COVID-19 post-pandemic times.
metadata.lang: en_GB
metadata.name: dc.description.sponsorship
metadata.value: This study was supported by
  grants No. 21-15-00411 and No. 18-15-
  00391 from the Russian Science Foundation.
  This study was made possible through the
  support of the Applied Genetics Resource
  Facility of Moscow Institute of Physics and
  Technology (support grant No. 075-15-2021-
  684).
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Biological Сommunications;Volume 68; Issue 3
metadata.lang: -
metadata.name: dc.subject
metadata.value: COVID-19
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: SARS-CoV-2
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: 3D cell culture models
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: tumor microenvironment
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: malignant tumors
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: translational medicine
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: personalized medicine
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: drug development
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: oncology
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Cancer as a potential sequela of COVID-19 — should we modify 3D cell culture models accordingly?
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 07.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/44456/1/07.pdf
resources.format: Adobe PDF
resources.size: 836,08 kB