title: Features of lymphocyte differentiation in ANCA-associated and virus-associated glomerulonephritis in children
metadata.name: dc.contributor.author
metadata.value: Gurina, Olga P.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Dementyeva, Elena A.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Stepanova, Arina A.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Blinov, Alexander E.
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Varlamova, Olga N.
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2022-08-12T13:49:21Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2022-08-12T13:49:21Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2021-12
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Gurina O. P., Dementyeva E. A., Stepanova A. A., Blinov A. E., Varlamova O. N. Features of lymphocyte differentiation in ANCA-associated and virus-associated glomerulonephritis in children. Vestnik of Saint Petersburg University. Medicine, 2021, vol. 16, issue 4, pp. 227–233.
metadata.lang: en_GB
metadata.name: dc.identifier.other
metadata.value: https://doi.org/10.21638/spbu11.2021.401
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/37354
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: Glomerulonephritis is a heterogeneous group of immuno-inflammatory diseases. The purpose
  of the study: to analyze the subpopulation composition of lymphocytes in children with
  various types of glomerulonephritis. 50 children aged 1 to 16 years were examined: 1 group —
  17 children aged 1 to 16 years with ANCA-associated glomerulonephritis; 2 group — 33 patients
  aged 2 to 16 years with virus-associated glomerulonephritis. Diagnostics of the subpopulation
  composition of lymphocytes was performed by flow cytometry using non-flushing
  technology using a three-color combination of monoclonal antibodies. It was found that the
  development of ANCA-associated glomerulonephritis is accompanied by signs of immunodeficiency
  against the background of a relative increase in the content of T-lymphocyte subpopulations.
  Differentiation of lymphocytes in children with virus-associated glomerulonephritis
  is ambiguous: the process goes either along the path of activation of antiviral protection, or
  along the path of development of insufficient antiviral activity of immunocytes. In children
  with virus-associated glomerulonephritis, a decrease in the level of B-lymphocytes was found,
  correlating with hypoimmunoglobulinemia A, which is an additional factor in reducing resistance
  on the mucous membranes. The study of lymphocyte differentiation in the development
  of glomerulonephritis is important for identifying the main immunological mechanisms involved
  in the pathogenesis of these diseases.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: St Petersburg State University
metadata.lang: en_GB
metadata.name: dc.relation.ispartofseries
metadata.value: Vestnik of St Petersburg University. Medicine;Volume 16; Issue 4
metadata.lang: -
metadata.name: dc.subject
metadata.value: flow cytometry
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: lymphocyte subpopulations
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: lymphocyte phenotype
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: glomerulonephritis
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: children
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Features of lymphocyte differentiation in ANCA-associated and virus-associated glomerulonephritis in children
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 01.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/37354/1/01.pdf
resources.format: Adobe PDF
resources.size: 687,39 kB