title: Simultaneous determination of iron (II) and ascorbic acid in pharmaceuticas based on flow sandwich technique
metadata.name: dc.contributor.author
metadata.value: Vakh, Christina
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Freze, Elena
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Pochivalov, Alexsey
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Evdokimova, Ekaterina
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Kamencev, Mihail
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Moskvin, Leonid
metadata.lang: -
metadata.name: dc.contributor.author
metadata.value: Bulatov, Andrey
metadata.lang: -
metadata.name: dc.date.accessioned
metadata.value: 2016-04-17T20:27:27Z
metadata.lang: -
metadata.name: dc.date.available
metadata.value: 2016-04-17T20:27:27Z
metadata.lang: -
metadata.name: dc.date.issued
metadata.value: 2015-04-08
metadata.lang: -
metadata.name: dc.identifier
metadata.value: 10.1016/j.vascn.2015.03.006
metadata.lang: -
metadata.name: dc.identifier.citation
metadata.value: Journal of Pharmacological and Toxicological Methods 73 (2015) 56–62
metadata.lang: en_GB
metadata.name: dc.identifier.issn
metadata.value: 10.1016/j.vascn.2015.03.006
metadata.lang: -
metadata.name: dc.identifier.uri
metadata.value: http://hdl.handle.net/11701/2115
metadata.lang: -
metadata.name: dc.description.abstract
metadata.value: The simple and easy performed flow system based on sandwich technique has been developed for the simultaneous separate determination of iron (II) and ascorbic acid in pharmaceuticals. The implementation of sandwich technique assumed the injection of sample solution between two selective reagents and allowed the carrying out in reaction coil two chemical reactions simultaneously: iron (II) with 1,10-phenanthroline and ascorbic acid with sodium 2,6-dichlorophenolindophenol. For achieving of excellent repeatability and considerable reagent saving the various parameters such as flow rate, sample and reagent volumes, reaction coil length were also optimized. The limits of detection (LODs) obtained by using the developed flow sandwich-type approach were 0.2 mg L(-1) for iron (II) and 0.7 mg L(-1) for ascorbic acid. The suggested approach was validated according to the following parameters: linearity and sensitivity, precision, recoveries and accuracy. The sampling frequency was 41 h(-1).
metadata.lang: en_GB
metadata.name: dc.description.sponsorship
metadata.value: This work was supported by the Russian Foundation for Basic
  Research (project No. 13-03-00031-a). Scientific researches were
  performed at the Center for chemical analysis and materials research
  of St. Petersburg State University.
metadata.lang: en_GB
metadata.name: dc.language.iso
metadata.value: en
metadata.lang: en_GB
metadata.name: dc.publisher
metadata.value: Elsevier
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: Automation of pharmaceutical analysis
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: Flow analysis
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: Sandwich technique
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: Iron (II)
metadata.lang: en_GB
metadata.name: dc.subject
metadata.value: Ascorbic acid
metadata.lang: en_GB
metadata.name: dc.title
metadata.value: Simultaneous determination of iron (II) and ascorbic acid in pharmaceuticas based on flow sandwich technique
metadata.lang: en_GB
metadata.name: dc.type
metadata.value: Article
metadata.lang: en_GB
resources.filename: 1.pdf
resources.url: https://dspace.spbu.ru/bitstream/11701/2115/1/1.pdf
resources.format: Adobe PDF
resources.size: 973,6 kB